Evidence map›Paper›PMID 35006274›Full record

ArticleThe Journal of cell biology2022

Consensus nomenclature for dyneins and associated assembly factors.

Bryony Braschi, Heymut Omran, George B Witman, Gregory J Pazour, K Kevin Pfister, Elspeth A Bruford, Stephen M King

Open access · hybridAbstract read
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. CladeOScope-GSA: Revealing Evolutionary Associations Across Gene Sets.International journal of molecular sciences · 2026
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  12. Age-Associated Proteomic Changes in Human Spermatozoa.International journal of molecular sciences · 2025
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  14. Review
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  16. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Bryony BraschiHUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-5269-0985
Heymut OmranDepartment of General Pediatrics, University Hospital Muenster, Muenster, Germany.
George B WitmanDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA.ORCID 0000-0002-9497-9218
Gregory J PazourProgram in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Worcester, MA.ORCID 0000-0002-6285-8796
K Kevin PfisterCell Biology Department, School of Medicine University of Virginia, Charlottesville, VA.ORCID 0000-0002-7619-7263
Elspeth A BrufordHUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-8380-5247
Stephen M KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT.ORCID 0000-0002-5484-5530
European Bioinformatics Institute · GBUniversity of Massachusetts Chan Medical School · USUConn Health · USUniversity Hospital Münster · DEUniversity of Virginia · US

Funding

Intraflagellar Transport Proteins in MiceR01GM060992 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gregory J Pazour · 2001 to 2026
$10.3M
The Biology of Motile CiliaR35GM140631 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Stephen M King · 2021 to 2026
$4.2M
The Nomenclature of Human and Vertebrate GenesU24HG003345 · NHGRI · UNIVERSITY OF CAMBRIDGE · PI Elspeth Bruford · 2018 to 2026
$3.9M
Flagellar Motility and AssemblyR35GM122574 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WITMAN, GEORGE B · 2017 to 2021
$3.1M
NHGRI NIH HHS U24 HG003345NHGRI NIH HHS U24HG003345NIGMS NIH HHS R01 GM060992NIGMS NIH HHS R35 GM122574NIGMS NIH HHS R35 GM140631NIH HHS R35-GM140631Wellcome Trust 208349/Z/17/Z
6 · The paper itself

Abstract

Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility. Variants in multiple genes encoding dyneins, outer dynein arm (ODA) docking complex subunits, and cytoplasmic factors involved in axonemal dynein preassembly (DNAAFs) are associated with human ciliopathies and are of clinical interest. Therefore, clear communication within this field is particularly important. Standardizing gene nomenclature, and basing it on orthology where possible, facilitates discussion and genetic comparison across species. Here, we discuss how the human gene nomenclature for dyneins, ODA docking complex subunits, and DNAAFs has been updated to be more functionally informative and consistent with that of the unicellular green alga Chlamydomonas reinhardtii, a key model organism for studying dyneins and ciliary function. We also detail additional nomenclature updates for vertebrate-specific genes that encode dynein chains and other proteins involved in dynein complex assembly.

Indexed as

ConsensusTerminology as TopicAnimalsAxonemeDyneinsHumansPhenotypeReference StandardsDyneins

Identifiers

PMID35006274
PMCPMC8754002
OpenAlexW4206249520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.