Evidence map›Paper›PMID 35005746›Full record

ArticleWorld journal of psychiatry and mental health research2022

Comparison of the clinical efficacy of penicillin and ceftriaxone sodium in the treatment of neurosyphilis with psychiatric symptoms.

Shibin Wang, Wenming Gu, Yuping Cao, Hangxiao Zheng, Lei Zhang, Xiaoyun Guo, Wenzhong Chen, Xingguang Luo

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in World journal of psychiatry and mental health research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Shibin WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Wenming GuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Yuping CaoDepartment of Psychiatry, the Second Xiangya Hospital, Central South University; The China National Clinical Research Center for Mental Health Disorders; National Technology Institute of Psychiatry; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China.
Hangxiao ZhengShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Lei ZhangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Xiaoyun GuoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Wenzhong ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA, 06510.
Shanghai Jiao Tong University · CNShanghai Mental Health Center · CNYale University · US

Funding

Deep sequencing of genes in ethanol-metabolism pathway in alcoholismR21AA021380 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2014 to 2015
$339k
NIAAA NIH HHS R21 AA021380
6 · The paper itself

Abstract

objectiveTo compare the clinical efficacy of penicillin and ceftriaxone sodium in the treatment of neurosyphilis with psychiatric symptoms.

methods50 neurosyphilis with mental symptoms patients were randomly divided into penicillin group (4 million units, Q4h) and ceftriaxone sodium group (1 g, Q12h). The total treatment time was 14 and 15 days respectively.The activity of daily living scale (ADL), brief psychiatric rating scale (BPRS) and mini-mental state examination (MMSE) were scored as the measurement of efficiency in living ability, mental symptoms and cognitive function.

resultThere were no significant differences in ADL, MMSE and BPRS between the penicillin group and the ceftriaxone sodium treatment group (

conclusionPenicillin or ceftriaxone sodium are both effective in the aspect of mental symptoms, cognitive function and life ability among neurosyphilis with psychiatric symptoms patients.

Indexed as

ceftriaxone sodiumclinical efficacyneurosyphilispenicillinpsychiatric symptoms

Identifiers

PMID35005746
PMCPMC8740858
OpenAlexW4206870632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.