Evidence map›Paper›PMID 35005636›Full record

ArticleSTAR protocols2022

Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice.

Qi Wang, Bin Tang, Jianrong Tang

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qi WangDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Bin TangDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Jianrong TangDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Studying the effects and mechanisms of deep brain stimulation in Rett syndrome miceR01NS100738 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Jianrong Tang · 2018 to 2026
$3.3M
NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NINDS NIH HHS R01 NS100738
6 · The paper itself

Abstract

Deep brain stimulation (DBS) entails neurosurgery to implant electrodes in specific brain structures to modulate the behavior of a particular neural circuit. DBS is best known for treating advanced Parkinson disease and can potentially be applicable to other motor and even cognitive dysfunctions. Here, we describe a detailed protocol allowing for electrode preparation, surgical procedures, stimulation delivery, and field potential recordings in both anesthetized and behaving mice, and the benefit evaluation of DBS at the fimbria-fornix by using a fear conditioning test. For complete details on the use and execution of this protocol, please refer to Hao et al. (2015).

Indexed as

Deep Brain StimulationParkinson DiseaseAnimalsElectrodesFearFornix, BrainMiceBehaviorCognitive NeuroscienceModel OrganismsNeuroscience

Identifiers

PMID35005636
PMCPMC8715214
OpenAlexW4200213167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.