Evidence map›Paper›PMID 35005634›Full record

ArticleCurrent research in toxicology2022

Lead exposure induces dysregulation of constitutive heterochromatin hallmarks in live cells.

Oscar F Sánchez, Li F Lin, Junkai Xie, Jennifer L Freeman, Chongli Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. A wide survey of heavy metals-inducedCurrent research in toxicology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Oscar F SánchezDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Li F LinDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Junkai XieDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Jennifer L FreemanSchool of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
Chongli YuanDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead (Pb) is a heavy metal contaminant commonly found in air, soil, and drinking water due to legacy uses. Excretion of ingested Pb can result in extensive kidney damages due to elevated oxidative stress. Epigenetic alterations induced by exposure to Pb have also been implied but remain poorly understood. In this work, we assessed changes in repressive epigenetic marks, namely DNA methylation (

Indexed as

DNA methylationEpigeneticsH3K9me3Heterochromatin

Identifiers

PMID35005634
PMCPMC8717252
OpenAlexW4200144977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.