Evidence map›Paper›PMID 35005592›Full record

ArticleJournal of translational autoimmunity2021

The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway.

Paul Mh Tran, Sharad Purohit, Eileen Kim, Khaled Bin Satter, Diane Hopkins, Kathleen Waugh, Fran Dong, Suna Onengut-Gumuscu, Stephen S Rich, Marian Rewers and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Paul Mh TranCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Sharad PurohitCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Eileen KimCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Khaled Bin SatterCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Diane HopkinsCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Kathleen WaughBarbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO, 80045, USA.
Fran DongBarbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO, 80045, USA.
Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Marian RewersBarbara Davis Center for Diabetes, University of Colorado Denver, Mail Stop A-140, 1775 Aurora Court, Aurora, CO, 80045, USA.
Jin-Xiong SheCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA, 30912, USA.
Augusta University · USUniversity of Colorado Denver · USUniversity of Virginia · US

Funding

Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
Studies of the Immunopathogenesis of Type 1 DiabetesR01HD037800 · NICHD · UNIVERSITY OF FLORIDA · PI SHE, JIN-XIONG · 1999 to 2006
$4.6M
Proteomic changes/progression of human type 1 diabetesR33HD050196 · NICHD · AUGUSTA UNIVERSITY · PI SHE, JIN-XIONG · 2006 to 2008
$1.5M
Proteomic changes/progression of human type 1 diabetesR21HD050196 · NICHD · MEDICAL COLLEGE OF GEORGIA (MCG) · PI SHE, JIN-XIONG · 2004 to 2005
$715k
Deep Learning Based Genetic Risk Prediction for Type 1 DiabetesF30DK121461 · NIDDK · AUGUSTA UNIVERSITY · PI TRAN, PAUL · 2019 to 2021
$123k
NICHD NIH HHS R01 HD037800NICHD NIH HHS R21 HD050196NICHD NIH HHS R33 HD050196NIDDK NIH HHS F30 DK121461NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK032493NIDDK NIH HHS U01 DK062418
6 · The paper itself

Abstract

Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although the direction of effect differs. We assessed CCL-2 serum levels in a longitudinal cohort to clarify this association, combined with genetic data to elucidate the regulatory role of CCL-2 in T1D pathogenesis. The Diabetes Autoimmunity Study in the Young (DAISY) followed 310 subjects with high risk of developing T1D. Of these, 42 became persistently seropositive for islet autoantibodies but did not develop T1D (non-progressors); 48 did develop T1D (progressors). CCL-2 serum levels among the three study groups were compared using linear mixed models adjusting for age, sex, HLA genotype, and family history of T1D. Summary statistics were obtained from the CCL-2 protein quantitative trait loci (pQTL) and

Indexed as

AutoimmuneCCL2CCR2DAISYFine mappingMCP1T1D

Identifiers

PMID35005592
PMCPMC8716652
OpenAlexW3207307715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.