ArticleCanadian journal of pain = Revue canadienne de la douleur2018
What is the relative contribution of biological and psychosocial factors to the generation of hypoxia headache?
Article in Canadian journal of pain = Revue canadienne de la douleur, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Investigating whether socially acquired nocebo effects can spread to other treatments.Scientific reports · 2025Trial
- Positive social modeling attenuates nocebo side effects.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Trial
- Negative expectations and related nocebo effects in shoulder pain: a perspective for clinicians and researchers.Pain management · 2025Review
- Nocebo and the contribution of psychosocial factors to the generation of pain.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- The need to investigate nocebo effects in more detail.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe biopsychosocial model claims that illness is generated by both biological and psychosocial factors. Accordingly, several studies have shown that both factors contribute to the generation of pain.
aimsThe aim of the present study is to manipulate biological, psychological, and social factors in hypobaric hypoxia headache in order to understand their relative contribution to the generation of headache pain.
methodsHealthy subjects were subdivided into three groups and brought to our high-altitude labs for the assessment of hypoxia-induced headache, blood oxygen saturation (SO
resultsAlthough none of the three groups differed significantly for SO
conclusionsThese findings indicate that biological, psychological, and social factors are additive not only in the generation of headache but also for the biochemical changes related to hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.