Evidence map›Paper›PMID 35005289›Full record

ArticleHeliyon2021

Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis

Utpal Kumar Adhikari, Elif Sakiz, Umma Habiba, Meena Mikhael, Matteo Senesi, Monique Antoinette David, Gilles J Guillemin, Lezanne Ooi, Tim Karl, Steven Collins and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. What is the role of lipids in prion conversion and disease?Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Utpal Kumar AdhikariSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Elif SakizSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Umma HabibaSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Meena MikhaelSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Matteo SenesiAustralian National Creutzfeldt-Jakob Disease Registry (ANCJDR), The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Australia.
Monique Antoinette DavidSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Gilles J GuilleminDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia.
Lezanne OoiIllawarra Health and Medical Research Institute, Wollongong, 2522, NSW, Australia.
Tim KarlSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Steven CollinsAustralian National Creutzfeldt-Jakob Disease Registry (ANCJDR), The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Australia.
Mourad TayebiSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Camden and Campbelltown Hospitals · AUThe Royal Melbourne Hospital · AUMacquarie University · AUUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous reports highlighted the neurotoxic effects caused by some motif-specific anti-PrP

Indexed as

Anti-PrP antibodiesApoptosisCellular prion proteinMicrogliaMicroglia cell line (N11)Neuroblastoma cell line (N2a)Primary neuronal cells

Identifiers

PMID35005289
PMCPMC8715334
OpenAlexW4225679665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.