ArticleAlzheimer's & dementia (New York, N. Y.)2021
Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades.
Article in Alzheimer's & dementia (New York, N. Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Eyes on dementia: an overview of the interplay between eye movements and cognitive decline.Journal of medicine and life · 2023Pooled it
- Eye-tracking training improves the learning and memory of children with learning difficulty.Scientific reports · 2022Trial
- Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy.Diagnostics (Basel, Switzerland) · 2026Review
- A novel eye-tracking digital marker outperforms plasma biomarkers in detecting cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Eye tracking as a digital biomarker in neurodegenerative diseases.Journal of neurology · 2026Review
- Review
- Validation of reading as a predictor of mild cognitive impairment.Scientific reports · 2025Article
- Assessing Cognition in Kidney Failure Using Virtual Reality Technology: A Clinical Research Protocol.Canadian journal of kidney health and disease · 2025Article
- Eye movement abnormalities in Alzheimer's disease and other neurodegenerative dementias: insights from current evidence and priorities for future research.Frontiers in ophthalmology · 2025Review
- Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases - Current Insights.Eye and brain · 2024Review
- Clinical utility of square-wave jerks in neurology and psychiatry.Frontiers in ophthalmology · 2023Review
- Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias.Frontiers in aging neuroscience · 2023Article
- Distinctive visual tasks for characterizing mild cognitive impairment and dementia using oculomotor behavior.Frontiers in aging neuroscience · 2023Article
- A Perspective: Challenges in Dementia Research.Medicina (Kaunas, Lithuania) · 2022Article
- Ocular myasthenia gravis saccades as a measure of extraocular muscle function.Frontiers in ophthalmology · 2022Article
- Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Eye tracking as a diagnostic tool in Alzheimer's disease, mild cognitive impairment, and related dementias: a systematic review.Alzheimer's & dementia (Amsterdam, Netherlands)Review
- Review
- AI-powered analysis of affective dimensions in speech and its relevance for FTD diagnosis.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionOculomotor function has not been systematically studied in frontotemporal dementia (FTD) and yet may offer a simple target to monitor disease activity.
methodsWe assessed fixation stability, smooth pursuit, pro-saccades, and anti-saccades using the Eyelink 1000-plus eye-tracker in 19 individuals with behavioral variant FTD (bvFTD) and 22 controls. Neuroanatomical correlates were assessed using a region of interest magnetic resonance imaging (MRI) analysis.
resultsMeasures of fixation stability were impaired in the bvFTD group compared with controls. However, performance did not differ from controls in the pro-saccade tasks except in the vertical overlap condition. The bvFTD group performed worse in the anti-saccade task, which correlated strongly with executive function. Neural correlates included the orbitofrontal and ventromedial prefrontal cortices and striatum for fixation stability, and the dorsolateral prefrontal and parietal cortices and striatum for anti-saccades. DISCUSSION: Overall, oculomotor function is abnormal in bvFTD, with performance likely related to impairment of inhibitory control and executive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.