ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 6 citations in OpenAlex.
- Stages of objective memory impairment are associated with accelerated brain aging.Scientific reports · 2026Article
- Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.Alzheimer's research & therapy · 2025Article
- Assessing Stages of Objective Memory Impairment and neuroimaging as risk factors of incident cognitive impairment.Journal of the International Neuropsychological Society : JINS · 2025Article
- Traffic-related air pollution andFrontiers in dementia · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease.The journal of prevention of Alzheimer's disease · 2024Article
- Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals.Neurology · 2023Article
- Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2023Article
- Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study.Neurology · 2022Article
- Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
introductionTo assess the relationship between memory performance defined by the Stages of Objective Memory Impairment (SOMI) system and the Alzheimer's disease (AD) ATN (amyloid beta [A], pathologic tau [T], and neurodegeneration [N]) biomarker system.
methodsWe used data from the Harvard Aging Brain Study cohort to estimate the level of ATN biomarkers: amyloid beta (C-Pittsburgh compound B-positron emission tomography [PET]), tau (F-18-flortaucipir [FTP] PET), and neurodegeneration (magnetic resonance imaging volumetrics). We assessed the cross-sectional relationship of SOMI classification with global amyloid levels, entorhinal and inferior temporal tau deposition, and hippocampal atrophy.
resultsParticipants with both memory storage and retrieval deficits (SOMI-3, -4) had smaller hippocampal volumes and higher entorhinal and inferior temporal tau burden than participants with no memory impairment (SOMI-0) or mild retrieval difficulty (SOMI-1). Amyloid burden did not differ among SOMI stages. DISCUSSION: This pilot supports the close relationship between tau pathology and memory impairment across the AD continuum. SOMI may be useful to determine eligibility for randomized controlled trials prior to the assessment of biomarker status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.