Evidence map›Paper›PMID 35005149›Full record

ArticleData in brief2022

Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach.

Polina V Zhdanova, Alexander A Ishchenko, Alexander A Chernonosov, Dmitry O Zharkov, Vladimir V Koval

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Polina V ZhdanovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibisk, Russia.
Alexander A IshchenkoGroupe «Réparation de l'ADN», Equipe Labellisée par la Ligue Nationale contre le Cancer, CNRS UMR 8200, Univ. Paris-Sud, Université Paris-Saclay, Villejuif F-94805, France.
Alexander A ChernonosovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibisk, Russia.
Dmitry O ZharkovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibisk, Russia.
Vladimir V KovalInstitute of Chemical Biology and Fundamental Medicine SB RAS, Novosibisk, Russia.
Siberian Branch of the Russian Academy of Sciences · RUInstitute of Chemical Biology and Fundamental Medicine · RULa Ligue Contre le Cancer · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix-two-turn-helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure of hNEIL2 has not yet been determined. This data article describes a powerful combination of hydrogen-deuterium exchange mass spectrometry, homology modeling, and molecular dynamics simulations for protein conformational dynamics analysis. The data supplied in this work are related to the research article entitled "Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry".

Indexed as

Base excision repairCD, circular dichroismDNA damageDNA glycosylasesDNA repairDTT, (2S,3S)-1,4-Bis(sulfanyl)butane-2,3-diolESI, electrospray ionizationHDX-MSHDX-MS, hydrogen-deuterium exchange mass spectrometryHEPES, 2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acidhNEIL2, human endonuclease VIII-like 2 proteinIPTG, Propan-2-yl 1-thio-β-D-galactopyranosideLB, Lysogeny brothLC-MS, liquid chromatography–mass spectrometryMD, molecular dynamicsMDTRA, Molecular Dynamics Trajectory Reader & AnalyzerMolecular dynamicsNEIL2PDB, Protein Data BankRMSD, root-mean-square deviationSDS-PAGE, sodium dodecyl sulphate–polyacrylamide gel electrophoresisStructural dynamicsTCEP, 3,3’,3’’-Phosphanetriyltripropanoic acid

Identifiers

PMID35005149
PMCPMC8717250
OpenAlexW4200459250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.