A dataset describing glycolytic inhibitors overcoming the underestimation of maximal mitochondrial oxygen consumption rate in oligomycin-treated cells.

Juliana S Ruas, Edilene S Siqueira-Santos, Claudia D C Navarro, Roger F Castilho

Open access · goldAbstract read

In one paragraph

Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 55% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

ATP synthase inhibition, an overlooked confounding factor in the mitochondrial stress test.PloS one · 2025
Article
A dataset describing glycolytic inhibitors overcoming the underestimation of maximal mitochondrial oxygen consumption rate in oligomycin-treated cells.Data in brief · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Juliana S RuasDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.

Edilene S Siqueira-SantosDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.

Claudia D C NavarroDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.

Roger F CastilhoDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.

Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determination of oxygen consumption is one of the most valuable methodologies to evaluate mitochondrial (dys)function. Previous studies demonstrated that a widely used protocol, consisting of adding the ATP synthase inhibitor oligomycin before mitochondrial respiratory uncoupling by sequential addition of a protonophore (e.g., carbonyl cyanide 3-chlorophenyl hydrazone [CCCP]), may lead to underestimation of maximal oxygen consumption rate (OCR

Indexed as

2-Deoxi-D-glucoseMitochondriaMitochondrial membrane potentialOligomycinOxygen consumptionSpare respiratory capacityTumor cell

Identifiers

PMID35005137

DOI10.1016/j.dib.2021.107739

PMCPMC8718714

OpenAlexW4200014490

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.