ArticleBone reports2022
Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?
Article in Bone reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Radiomics identifies distinct cortical bone texture alterations in patients with CKD using HR-pQCT.Bone research · 2026Article
- Identification of water compartment in bone using ATR-FTIR spectroscopy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026Article
- Longitudinal and radial microgradients in porosity and canal diameter in femur bone and its implications for bone regeneration and bone repair implants.Frontiers in bioengineering and biotechnology · 2026Article
- Nanostructural changes in bone quality in a mouse model of chronic kidney disease and treatment with calcitonin.Bone reports · 2025Article
- Water and Collagen: A Mystery Yet to Unfold.Biomacromolecules · 2025Review
- The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.Calcified tissue international · 2025Article
- Bone Quality and Mineralization and Effects of Treatment in Osteogenesis Imperfecta.Calcified tissue international · 2024Review
- Review
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- Article
- Article
- Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues.Science advances · 2024Article
- Article
- Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Resorbable conductive materials for optimally interfacing medical devices with the living.Frontiers in bioengineering and biotechnology · 2024Review
- Bone mineral metabolism and different indices of skeletal health of Ladakhi women living at high altitude.Osteoporosis and sarcopenia · 2023Article
- Article
- 3D Tortuosity and Diffusion Characterization in the Human Mineralized Collagen Fibril Using a Random Walk Model.Bioengineering (Basel, Switzerland) · 2023Article
- Smart Biomechanical Adaptation Revealed by the Structure of Ostrich Limb Bones.Biomimetics (Basel, Switzerland) · 2023Article
- Severe COVID-19-A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence mechanical properties and tissue quality. There is a growing appreciation for how water can dynamically change due to age, disease, and treatment. A key emerging area related to bone mechanical and tissue properties lies in differentiating the role of water in its four different compartments, including free/pore water, water loosely bound at the collagen/mineral interfaces, water tightly bound within collagen triple helices, and structural water within the mineral. This review summarizes our current knowledge of bone water across the four functional compartments and discusses how alterations in each compartment relate to mechanical changes. It provides an overview on the advent of- and improvements to- imaging and spectroscopic techniques able to probe nano-and molecular scales of bone water. These technical advances have led to an emerging understanding of how bone water changes in various conditions, of which aging, chronic kidney disease, diabetes, osteoporosis, and osteogenesis imperfecta are reviewed. Finally, it summarizes work focused on therapeutically targeting water to improve mechanical properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.