Evidence map›Paper›PMID 35005095›Full record

ArticleBio-protocol2021

Nicole R Gould, Jenna M Leser, Olivia M Torre, Ramzi J Khairallah, Christopher W Ward, Joseph P Stains

Open access · greenAbstract read
In one paragraph

Article in Bio-protocol, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load.Biochemical and biophysical research communications · 2024
    Article
  2. Review
  3. Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicole R GouldDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, USA.
Jenna M LeserDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, USA.
Olivia M TorreDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, USA.
Ramzi J KhairallahMyologica, LLC., New Market, MD, USA.
Christopher W WardDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, USA.
Joseph P StainsDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, USA.
University of Maryland, Baltimore · US

Funding

TRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9M
Spatial Control of Bone Remodeling by Gap Junction-Communicated cAMPR01AR063631 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI STAINS, JOSEPH P. · 2013 to 2024
$3.3M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Microtubule Regulated Mechanotransduction in Skeletal MuscleR01AR071618 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2017 to 2021
$2.6M
Osteocyte CaMKII as a Critical Regulator of Bone Physiology and AnabolismR01AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph P. Stains · 2018 to 2026
$2.6M
The Role of Reactive Oxygen Species in Osteocyte Mechano-Transduction and Sclerostin RegulationF31AR077974 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI GOULD, NICOLE R. · 2021 to 2021
$34k
NHLBI NIH HHS R01 HL142290NIAMS NIH HHS F31 AR077974NIAMS NIH HHS R01 AR063631NIAMS NIH HHS R01 AR071614NIAMS NIH HHS R01 AR071618NIGMS NIH HHS T32 GM008181
6 · The paper itself

Abstract

Bone is a dynamic tissue that adapts to changes in its mechanical environment. Mechanical stimuli pressurize interstitial fluid in the lacunar-canalicular system within the bone matrix, causing fluid shear stress (FSS) across bone embedded, mechano-sensitive osteocytes. Therefore, modeling this mechanical stimulus

Indexed as

Calcium/Calmodulin-dependent kinase II (CaMKII)Fluid flowFluid shear stress (FSS)Mechano-transductionOsteocyteSclerostinSignal transduction

Identifiers

PMID35005095
PMCPMC8678913
OpenAlexW4205555640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.