ArticleMovement disorders clinical practice2022
Demographic Influences on the Relationship Between Fatigue and Quality of Life in Parkinson's Disease.
Article in Movement disorders clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Client Perceptions of the Individual Packer Managing Fatigue Program: A Mixed-Method Evaluation.OTJR : occupation, participation and health · 2024Trial
- Association between anxiety, depression, and fatigue in elderly patients with Parkinson's disease.World journal of psychiatry · 2026Article
- Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson's disease-related fatigue.Frontiers in aging neuroscience · 2025Article
- The impact of fatigue severity and depression level on the quality of life in individuals with Parkinson's disease in Taiwan.Frontiers in psychiatry · 2024Article
- The Impact of Nonmotor Symptoms on Health-Related Quality of Life in Parkinson's Disease: A Network Analysis Approach.Journal of clinical medicine · 2023Article
- Predicting the fatigue in Parkinson's disease using inertial sensor gait data and clinical characteristics.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD).
objectivesTo determine whether demographic characteristics modify the relationship between fatigue and HR-QOL.
methodsPatients with PD in the Fox Insight study completed the Parkinson Fatigue Scale (PFS-16) and Geriatric Depression Scale (GDS-15). Linear regression examined the relationship between the PFS-16 and Parkinson Disease Quality of Life, as modified by age, sex, and GDS-15.
resultsA total of 1029 participants (44% female, mean age 67.4 years, and mean disease duration 4.6 years) were included in this analysis. Multivariable regression modeling demonstrated a negative effect modification for age (β = -0.07,
conclusionThe association between fatigue and worse HR-QOL is greater at younger ages and in individuals with more depressive symptoms. Targeted therapeutics for these individuals may provide the greatest impact on fatigue in PD.
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