Evidence map›Paper›PMID 35005032›Full record

ArticleJournal of immunology research2021

Elevated Serum Chloride Levels Contribute to a Poor Prognosis in Patients with IgA Nephropathy.

Yaling Zhai, Xingchen Yao, Yuanyuan Qi, Jingge Gao, Yazhuo Chen, Xinnian Wang, Feng Wu, Zhanzheng Zhao

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yaling ZhaiDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xingchen YaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0001-6283-9563
Yuanyuan QiDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jingge GaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yazhuo ChenDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinnian WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Feng WuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhanzheng ZhaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0001-6079-1631
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe identification of reliable prognostic factors is a crucial requirement for patients with IgA nephropathy (IgAN). Here, we explored the relationship between serum chloride levels and prognosis in patients with IgAN.

methodsWe recruited all patients with primary IgAN, as diagnosed by renal biopsy, between 1

resultsCompared with patients in the high chloride group, patients in the low chloride group had significantly lower levels of 24-hour urinary total protein (24 h-UTP), serum creatinine (sCr), and higher levels of hemoglobin (Hb), albumin (all

conclusionsA serum chloride level ≥ 105.4 mmol/l was identified as a significant and independent risk factor for the prognosis of patients with IgAN. A predictive prognosis model was generated using serum chloride, sCr, T, hypertension, and Hb; this model exhibited a good predictive effect.

Indexed as

AdultBiomarkersChloridesDisease ProgressionFemaleFollow-Up StudiesGlomerulonephritis, IGAHumansMaleMiddle AgedModels, StatisticalPrognosisRetrospective StudiesRiskYoung AdultBiomarkersChlorides

Identifiers

PMID35005032
PMCPMC8739901
OpenAlexW3203837334

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.