Evidence map›Paper›PMID 35005020›Full record

ArticleBioMed research international2021

DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8.

Xianjun Chen, Yong'an Jiang, Jiayu Liu, Changfeng Wang, Dengfeng Wan, Ai'jun Liang, Jingxing Leng, Yu Yang, Hui Xiang, Ru'en Liu

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xianjun ChenDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0003-2041-2638
Yong'an JiangDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0001-5337-1786
Jiayu LiuDepartment of Neurosurgery, Peking University People's Hospital, 11th Xizhimen South St. Beijing 100044, China.ORCID https://orcid.org/0000-0001-6976-4568
Changfeng WangDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0001-6646-9811
Dengfeng WanDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-2446-1288
Ai'jun LiangDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-9429-4366
Jingxing LengDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-2626-1693
Yu YangDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-8988-0790
Hui XiangDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-2085-2601
Ru'en LiuDepartment of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-2405-5597
Nanchang University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the predictive value of milk fat globule epidermal growth factor 8 (MFG-E8) in the occurrence of delayed cerebral ischemia (DCI) after an aneurysmal subarachnoid hemorrhage (aSAH).

methodsWe recruited 32 patients with aSAH as the case group and 24 patients with unruptured aneurysms as the control group. Serum MFG-E8 levels were measured by western blot and enzyme-linked immunosorbent assay. We analyzed the relationship between MFG-E8 levels and the risk of DCI.

resultsThe levels of serum MFG-E8 in the case group (mean = 11160.9 pg/mL) were significantly higher than those in the control group (mean = 3081.0 pg/mL,

conclusionMFG-E8 may be a useful predictive marker for DCI after an aSAH and could be a promising surrogate end point.

Indexed as

AgedAntigens, SurfaceBrain IschemiaCerebral InfarctionFemaleHumansMaleMiddle AgedMilk ProteinsProspective StudiesROC CurveSubarachnoid HemorrhageAntigens, SurfaceMFGE8 protein, humanMilk Proteins

Identifiers

PMID35005020
PMCPMC8741362
OpenAlexW4206473066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.