Evidence map›Paper›PMID 35004847›Full record

ArticleFrontiers in molecular biosciences2021

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion.

Yifan Ge, Sivakumar Boopathy, Tran H Nguyen, Camila Makhlouta Lugo, Luke H Chao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yifan GeDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States.
Sivakumar BoopathyDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States.
Tran H NguyenDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States.
Camila Makhlouta LugoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States.
Luke H ChaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · US

Funding

Probing structural and biophysical mechanisms of mitochondrial membrane ultrastructureR35GM142553 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Luke H. Chao · 2021 to 2026
$2.6M
NIGMS NIH HHS R35 GM142553
6 · The paper itself

Abstract

Cardiolipin is a tetra-acylated di-phosphatidylglycerol lipid enriched in the matrix-facing (inner) leaflet of the mitochondrial inner membrane. Cardiolipin plays an important role in regulating mitochondria function and dynamics. Yet, the mechanisms connecting cardiolipin distribution and mitochondrial protein function remain indirect. In our previous work, we established an

Indexed as

cardiolipinmembrane asymmetrymembrane heterogeneitymitochondrial fusionOPA1

Identifiers

PMID35004847
PMCPMC8728091
OpenAlexW4226378057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.