Evidence map›Paper›PMID 35004702›Full record

ReviewFrontiers in cell and developmental biology2021

Role of Exosomal Non-Coding RNAs in Bone-Related Diseases.

Hang Li, Qiyue Zheng, Xinyan Xie, Jiaojiao Wang, Haihong Zhu, Haoye Hu, Hao He, Qiong Lu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hang LiDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Qiyue ZhengDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Xinyan XieDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Jiaojiao WangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Haihong ZhuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Haoye HuDepartment of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China.
Hao HeDepartment of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Qiong LuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone-related diseases seriously affect the lives of patients and carry a heavy economic burden on society. Treatment methods cannot meet the diverse clinical needs of affected patients. Exosomes participate in the occurrence and development of many diseases through intercellular communication, including bone-related diseases. Studies have shown that exosomes can take-up and "package" non-coding RNAs and "deliver" them to recipient cells, thereby regulating the function of recipient cells. The exosomal non-coding RNAs secreted by osteoblasts, osteoclasts, chondrocytes, and other cells are involved in the regulation of bone-related diseases by inhibiting osteoclasts, enhancing chondrocyte activity and promoting angiogenesis. Here, we summarize the role and therapeutic potential of exosomal non-coding RNAs in the bone-related diseases osteoporosis, osteoarthritis, and bone-fracture healing, and discuss the clinical application of exosomes in patients with bone-related diseases.

Indexed as

bone-related diseasesexosomesnon-coding RNAsosteoarthritisosteoporosis

Identifiers

PMID35004702
PMCPMC8733689
OpenAlexW4200000434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.