Evidence map›Paper›PMID 35004643›Full record

ArticleFrontiers in bioengineering and biotechnology2021

RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation.

Wenjian Liu, Jing Su, Qiang Shi, Jinlei Wang, Xiao Chen, Shizhong Zhang, Mengkao Li, Jie Cui, Cundong Fan, Beibei Sun and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Advancing glioblastoma therapy with surface-modified nanoparticles.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  3. Co-adjuvant nano particles for hepatocellular carcinoma radiotherapy treatment.Journal of the Egyptian National Cancer Institute · 2025
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Wenjian LiuDepartment of Oncology, Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, China.
Jing SuDepartment of Geriatrics, Taian City Central Hospital, Taian, China.
Qiang ShiDepartment of Oncology, Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, China.
Jinlei WangDepartment of Internal Medicine, Taian Traffic Hospital, Taian, China.
Xiao ChenDepartment of Neurosurgery, Taian City Central Hospital, Taian, China.
Shizhong ZhangDepartment of Neurosurgery, Taian City Central Hospital, Taian, China.
Mengkao LiDepartment of Neurosurgery, Taian City Central Hospital, Taian, China.
Jie CuiDepartment of Oncology, Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, China.
Cundong FanDepartment of Oncology, Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, China.
Beibei SunDepartment of Oncology, Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, China.
Guojun WangDepartment of Neurosurgery, Taian City Central Hospital, Taian, China.
Shandong First Medical University · CNTaian City Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy is still one of the most common ways to treat human glioblastoma in clinic. However, severe side effects limited its clinic application. Design of cancer-targeted drugs with high efficiency and low side effect is urgently needed. Herein, silver nanoparticles (Ag NPs) and nano-selenium (Se NPs) conjugated with RGD peptides (Ag@Se@RGD NPs) to target integrin high-expressed glioma were designed. The results found that Ag@Se@RGD NPs displayed stable particle size and morphology in physiological condition, and induced significant integrin-targeted intracellular uptake. Ag@Se@RGD NPs

Indexed as

apoptosisgliomaMAPKsmitochondrial dysfunctionreactive oxygen species

Identifiers

PMID35004643
PMCPMC8733670
OpenAlexW4200578901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.