Evidence map›Paper›PMID 35004620›Full record

ArticleFrontiers in chemistry2021

Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian.

Nicole E Avalon, Alison E Murray, Hajnalka E Daligault, Chien-Chi Lo, Karen W Davenport, Armand E K Dichosa, Patrick S G Chain, Bill J Baker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Dietary supplementation withAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicole E AvalonDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Alison E MurrayDivision of Earth and Ecosystem Sciences, Desert Research Institute, Reno, NV, United States.
Hajnalka E DaligaultLos Alamos National Laboratory, Los Alamos, NM, United States.
Chien-Chi LoLos Alamos National Laboratory, Los Alamos, NM, United States.
Karen W DavenportLos Alamos National Laboratory, Los Alamos, NM, United States.
Armand E K DichosaLos Alamos National Laboratory, Los Alamos, NM, United States.
Patrick S G ChainLos Alamos National Laboratory, Los Alamos, NM, United States.
Bill J BakerDepartment of Chemistry, University of South Florida, Tampa, FL, United States.
Los Alamos National Laboratory · USUniversity of South Florida · USDesert Research Institute · US

Funding

Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesisR21CA205932 · NCI · DESERT RESEARCH INSTITUTE · PI BAKER, BILL J, CHAIN, PATRICK S. G. · 2018 to 2019
$427k
NCI NIH HHS R21 CA205932
6 · The paper itself

Abstract

Complex interactions exist between microbiomes and their hosts. Increasingly, defensive metabolites that have been attributed to host biosynthetic capability are now being recognized as products of host-associated microbes. These unique metabolites often have bioactivity targets in human disease and can be purposed as pharmaceuticals. Polyketides are a complex family of natural products that often serve as defensive metabolites for competitive or pro-survival purposes for the producing organism, while demonstrating bioactivity in human diseases as cholesterol lowering agents, anti-infectives, and anti-tumor agents. Marine invertebrates and microbes are a rich source of polyketides. Palmerolide A, a polyketide isolated from the Antarctic ascidian

Indexed as

Antarctic microbiologybiosynthetic gene clustersmacrolidemarine natural productssecondary metabolitestrans-AT type I polyketide synthase

Identifiers

PMID35004620
PMCPMC8739492
OpenAlexW4226048296

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.