Evidence map›Paper›PMID 35004606›Full record

ArticleFrontiers in chemistry2021

Revealing the Toxicity-Enhancing Essence of Glycyrrhiza on

Yuqin Yang, Feifei Li, Mengmeng Yan, Shan Chen, Desheng Cai, Xiaojing Liu, Nana Han, Zhihua Yuan, Jihui Lu, Yaozhi Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Revealing the Mechanism ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yuqin YangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Feifei LiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Mengmeng YanSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Shan ChenSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Desheng CaiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Xiaojing LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Nana HanSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Zhihua YuanSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Jihui LuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Yaozhi ZhangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Qiang MaChinese Academy of Inspection and Quarantine, Beijing, China.
Penglong WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Haimin LeiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine · CNChinese Academy of Inspection and Quarantine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers often focus on the mechanisms of synergistic agents, a few explore drug combinations that enhance toxicity, while few have studied the internal mechanism of compatibility enhancement in chemical level. Herein, we present a comprehensive analysis based on ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) and a self-assembled supramolecular strategy, which reveals the toxicity-enhancing essence of glycyrrhizic acid originated in licorice when combined with

Indexed as

genkwa flosglycyrrhizic acidself-assembled supramolecular technologytoxicityultra-high-performance liquid chromatography coupled with quadrupole-orbitrap high-resolution mass spectrometry

Identifiers

PMID35004606
PMCPMC8733466
OpenAlexW4200485392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.