ReviewImmunoTargets and therapy2021
Pathophysiology of Non-IgE-Mediated Food Allergy.
Review in ImmunoTargets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
- Prevalence of Feeding Difficulties in Children With Non-IgE Mediated Food Allergies: A Systematic Review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Distinct Inflammation-Associated Microbiome Signatures in Pediatric Non-IgE-Mediated Food Allergy.International journal of molecular sciences · 2026Article
- Assessment of Allergenic Potential for Cross-Reactivity of Olive (Food science & nutrition · 2026Article
- Oral food challenges in FPIES: A narrative review and proposals for emergency and home-based management of acute FPIES reaction.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Genetic Variants of Thymic Stromal Lymphopoietin and Non-IgE-Mediated Food Allergy.International journal of molecular sciences · 2026Article
- Hen's Egg Allergy: Immunological Mechanisms, Epidemiology, and Predictors of Persistence in Childhood.Allergy, asthma & immunology research · 2026Review
- Review
- From the Field - Supporting Families as They Navigate Infant Food Allergies.Journal of human lactation : official journal of International Lactation Consultant Association · 2026Review
- Development of an intestinal allergy model to evaluate the initial introduction of infant rice cereal.NPJ science of food · 2025Article
- Eosinophil ETosis in severe non-IgE-mediated gastrointestinal food allergy, a neonatal necrotizing enterocolitis: A case report.Asia Pacific allergy · 2025Article
- Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren's Syndrome.Nutrients · 2025Article
- Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025Review
- Aeroportia and pneumatosis intestinalis in infants with food protein-induced-allergic proctocolitis: A presentation of two cases.JPGN reports · 2025Article
- Impact of Food Allergies on the Food Safety and Life Quality of Adults in Spain.Foods (Basel, Switzerland) · 2025Article
- Article
- Scientific developments in understanding food allergy prevention, diagnosis, and treatment.Frontiers in immunology · 2025Review
- Clinical prediction model by machine learning to determine the results of maternal dietary avoidance in food protein-induced allergic proctocolitis infants.Frontiers in pediatrics · 2025Article
- Gluten and its relationship with inflammation and Parkinson's Disease: A literature review.AIMS neuroscience · 2025Review
- Cord blood methylation at TNFRSF17 is associated with early allergic phenotypes.Immunologic research · 2024Article
- The Role of Regulatory B Lymphocytes in Allergic Diseases.Biomedicines · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result in multi-organ system anaphylaxis, the non-IgE mediated food allergies primarily affect the gastrointestinal tract. This review outlines the clinical manifestations, epidemiology, pathophysiology, and management of non-IgE-mediated food allergies. An updated literature search of selected non-IgE-mediated food allergies was conducted for this review using PubMed database to the current year (2021). Reviewed disorders include food protein-induced enterocolitis syndrome (FPIES), food-protein enteropathy (FPE), food protein-induced allergic proctocolitis (FPIAP), and eosinophilic gastrointestinal disorders (EGIDs) such as eosinophilic esophagitis (EoE). While extensive gains have been made in understanding FPIES, FPIAP, FPE, and EoE, more information is needed on the pathophysiology of these food allergies. Similarities among them include involvement of innate immunity, T-lymphocyte processes, alteration of the intestinal lumen at the cellular level with the appearance of inflammatory cells and associated histologic changes, and specific cytokine profiles suggesting food-specific, T-cell, and immune-mediated responses. While FPIES and FPIAP typically resolve in early childhood, EGIDs typically do not. Emerging new therapies for EoE offer promise of additional treatment options. Further studies identifying the immunopathogenesis, associated biomarkers, and mechanisms of tolerance are needed to inform prevention, diagnosis and management.
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