Evidence map›Paper›PMID 35004298›Full record

ArticleFrontiers in oncology2021

METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer.

Han-Guang Ruan, Wen-Chao Gu, Wen Xia, Yan Gong, Xue-Liang Zhou, Wen-Yan Chen, Juan Xiong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. The miR-338-5p/METTL3 axis regulates m6A modification to inhibit tumor progression in triple-negative breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Review
  4. Review
  5. Potential regulatory role of the mActa biochimica et biophysica Sinica · 2025
    Review
  6. Review
  7. Regulation of mFunctional & integrative genomics · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Non-coding RNA-Mediated N6-Methyladenosine (mNon-coding RNA research · 2024
    Review
  14. New insights into the regulation of METTL3 and its role in tumors.Cell communication and signaling : CCS · 2023
    Review
  15. Prognostic value of comprehensive typing based on m6A and gene cluster in TNBC.Journal of cancer research and clinical oncology · 2023
    Article
  16. Review
  17. The Key Role of RNA Modification in Breast Cancer.Frontiers in cell and developmental biology · 2022
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Han-Guang RuanDepartment of Breast Oncology, The Third Hospital of Nanchang, Nanchang, China.
Wen-Chao GuDepartment of Diagnostic of Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Wen XiaDepartment of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Yan GongDepartment of Breast Oncology, The Third Hospital of Nanchang, Nanchang, China.
Xue-Liang ZhouDepartment of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
Wen-Yan ChenDepartment of Breast Oncology, The Third Hospital of Nanchang, Nanchang, China.
Juan XiongDepartment of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, China.
Third Hospital of Nanchang · CNGunma University · JPJiangxi Provincial Cancer Hospital · CNNanchang University · CNSun Yat-sen University Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite N6-methyladenosine (m

Indexed as

circMETTL3m6AMETTL3miR-34c-3ptriple negative breast cancer

Identifiers

PMID35004298
PMCPMC8727604
OpenAlexW4200327164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.