ArticleTranslational lung cancer research2021
The combination of computed tomography features and circulating tumor cells increases the surgical prediction of visceral pleural invasion in clinical T1N0M0 lung adenocarcinoma.
Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 25 citations in OpenAlex.
- Preoperative prediction of visceral pleural invasion in clinical stage T1 invasive lung adenocarcinoma using intratumoral and peritumoral radiomics: a multicenter development, validation, and comparison study.BMC medical imaging · 2026Article
- CT predictors of visceral pleural invasion in subsolid nodular pulmonary adenocarcinoma: differences between direct and indirect tumor-pleura contact.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Observational
- Development of a risk scoring model for predicting visceral pleural invasion in clinical stage T1N0M0 lung adenocarcinoma.Journal of thoracic disease · 2026Article
- Integrated predictive model for visceral pleural invasion in small NSCLC with high clinical utility.NPJ precision oncology · 2026Article
- Predicting visceral pleural invasion in invasive adenocarcinoma with a maximum diameter ≤ 3 cm based onEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Redefining cancer care: harnessing circulating tumor cells' potential for improved diagnosis and prognosis.Cancer cell international · 2025Review
- Integrating radiomics features and CT semantic characteristics for predicting visceral pleural invasion in clinical stage Ia peripheral lung adenocarcinoma.Discover oncology · 2025Article
- Prediction of visceral pleural invasion of clinical stage IA lung adenocarcinoma based on computed tomography features.Translational cancer research · 2025Article
- Minimally invasive biomarkers for triaging lung nodules-challenges and future perspectives.Cancer metastasis reviews · 2025Review
- Factors associated with the distribution of brain metastases in lung cancer: a retrospective study.Clinical & experimental metastasis · 2024Article
- Baseline computed tomography imaging findings could assist in early diagnosis of visceral pleural invasion for newly discovered early subpleural non-small cell lung cancer: T1 or T2.Journal of thoracic disease · 2024Article
- Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma.Journal of cardiothoracic surgery · 2024Article
- Pleural Carcinoembryonic Antigen and Maximum Standardized Uptake Value as Predictive Indicators of Visceral Pleural Invasion in Clinical T1N0M0 Lung Adenocarcinoma.Journal of chest surgery · 2024Article
- Using the length of pleural tag to predetermine pleural invasion by lung adenocarcinomas.Frontiers in oncology · 2024Article
- Correlations between iodine uptake, invasive CT features and pleural invasion in adenocarcinomas with pleural contact.Scientific reports · 2023Article
- Multivariate analysis based on the maximum standard unit value ofDiagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Gene expression profiling of circulating tumor cells captured by MicroCavity Array is superior to enumeration in demonstrating therapy response in patients with newly diagnosed advanced and locally advanced non-small cell lung cancer.Translational lung cancer research · 2023Article
- Is lobectomy superior to sub-lobectomy in non-small cell lung cancer with pleural invasion? A population-based competing risk analysis.BMC cancer · 2022Article
- Risk analysis of visceral pleural invasion in malignant solitary pulmonary nodules that appear touching the pleural surface.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVisceral pleural invasion (VPI) is a clinical manifestation associated with a poor prognosis, and diagnosing it preoperatively is highly imperative for successful sublobar resection of these peripheral tumors. We evaluated the roles of computed tomography (CT) features and circulating tumor cells (CTCs) for improving VPI detection in patients with clinical T1N0M0 invasive lung adenocarcinoma.
methodsThree hundred and ninety-one patients were reviewed retrospectively in this study, of which 234 presented with a pleural tag or pleural contact on CT images. CTCs positive for the foliate receptors were enriched and analyzed prior to surgery. Logistic regression analyses were performed to assess the association of CT features and CTCs with VPI, and the receiver operating characteristic (ROC) curve was generated to compare the predictive power of these variables.
resultsPatients mostly underwent either segmentectomies (18.9%) or lobectomies (79.0%). Only 49 of the 234 patients with pleural involvement on CT showed pathologically confirmed VPI. Multivariate logistic regression analysis revealed that CTC level ≥10.42 FU/3 mL was a significant VPI risk factor for invasive adenocarcinoma cases ≤30 mm [adjusted odds ratio (OR) =4.62, 95% confidence interval (CI): 2.05-10.44, P<0.001]. Based on CT features, subgroup analyses showed that the solid portion size was a statistically significant independent predictor of VPI for these peripheral nodules with pleural tag, while the solid portion length of the interface was an independent predictor of pleural contact. The receiver operating curve analyses showed that the combination of CTC and CT features were highly predictive of VPI [area under the curve (AUC) =0.921 for pleural contact and 0.862 for the pleural tag, respectively].
conclusionsCTC, combined with CT features of pleural tag or pleural contact, could significantly improve VPI detection in invasive lung adenocarcinomas at clinical T1N0M0 stage prior to the patient's surgery.
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