Evidence map›Paper›PMID 35004253›Full record

ArticleTranslational lung cancer research2021

Blood digital polymerase chain reaction as a potential method to detect human epidermal growth factor receptor 2 amplification in non-small cell lung cancer.

Hui Qi, Anwen Xiong, Lei Jiang, Hardy Van, June Xu, Jing Wu, Qiaosong Zheng, Fabrizio Minervini, Dinora Polanco Alonso, Yifu Yang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Advances in Diagnosis and Treatment of HER2-positive Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Hui Qi *Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Anwen Xiong *Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Lei Jiang *School of Medicine, Tongji University, Shanghai, China.
Hardy VanAlphamab Oncology Ltd., Suzhou, China.
June XuAlphamab Oncology Ltd., Suzhou, China.
Jing WuGenetron Health (Beijing) Co. Ltd., Beijing, China.
Qiaosong ZhengGenetron Health (Beijing) Co. Ltd., Beijing, China.
Fabrizio MinerviniDepartment of Thoracic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Dinora Polanco AlonsoGroup of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain.
Yifu YangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liang WuDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNHospital Universitari Arnau de Vilanova · ESShanghai Jiao Tong University · CNShanghai Pulmonary Hospital · CNTongji University · CNUniversity of Lucerne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to verify the feasibility of human epidermal growth factor receptor-2 (

methodsA total of 112 fresh biopsy tissues and 88 blood samples from NSCLC patients were collected. The serum ctDNA was obtained from blood samples. The copy number of the

resultsROC analysis showed a good prediction result for

conclusionsBlood dPCR might be a potential method to detect

Indexed as

circulating tumor DNA (ctDNA)digital polymerase chain reaction (dPCR)human epidermal growth factor receptor 2 (HER2)Non-small cell lung cancer (NSCLC)overall survival (OS)

Identifiers

PMID35004253
PMCPMC8674588
OpenAlexW3216934409

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.