Evidence map›Paper›PMID 35003897›Full record

ArticleOncoimmunology2022

CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model.

Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L Choyke, Hisataka Kobayashi

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  5. Review
  6. Interleukin 15 (IL15)-based near-infrared photoimmunotherapy.Cancer immunology, immunotherapy : CII · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aki FurusawaMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-1339-4219
Ryuhei OkadaMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Fuyuki InagakiMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Hiroaki WakiyamaMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Takuya KatoMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Hideyuki FurumotoMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Hiroshi FukushimaMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Shuhei OkuyamaMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Peter L ChoykeMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Hisataka KobayashiMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Funding

Growth Factor Imaging and PhotoimmunotherapyZIABC010656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2024
$31.6M
Cancer-cell specific therapy: photo-immunotherapyZIABC011513 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KOBAYASHI, HISATAKA · 2013 to 2025
$15.5M
Intramural NIH HHS ZIA BC011513
6 · The paper itself

Abstract

Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that utilizes an antibody-photoabsorber-conjugate (AbPC) combined with NIR light. The AbPC is injected and binds to the tumor whereupon NIR light irradiation causes a photochemical reaction that selectively kills cancer cells. NIR-PIT is ideal for surface-located skin cancers such as melanoma. However, there is concern that the pigment in melanoma lesions could interfere with light delivery, rendering treatment ineffective. We investigated the efficacy of CD29- and CD44-targeted NIR-PIT (CD29-PIT and CD44-PIT, respectively) in the B16 melanoma model, which is highly pigmented. While CD29-PIT and CD44-PIT killed B16 cells

Indexed as

Infrared RaysMelanomaCell Line, TumorHumansImmunotherapyPhototherapyTumor MicroenvironmentCancerCD29melanomanear-infrared photoimmunotherapy (NIR-PIT)target molecule

Identifiers

PMID35003897
PMCPMC8741294
OpenAlexW4205789272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.