Regional changes with global brain hypometabolism indicates a physiological triage phenomenon and can explain shared pathophysiological events in Alzheimer's & small vessel diseases and delirium.

Sandeep K Gupta, Natalie Rutherford, Xenia Dolja-Gore, Tahne Watson, Balakrishnan R Nair

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Article in American journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sandeep K GuptaDepartment of Nuclear Medicine & PET, John Hunter and Calvary Mater Hospitals, Hunter Medical Research Institute (HMRI), University of Newcastle Newcastle, NSW, Australia.

Natalie RutherfordDepartment of Nuclear Medicine & PET, John Hunter and Calvary Mater Hospitals, Hunter Medical Research Institute (HMRI), University of Newcastle Newcastle, NSW, Australia.

Xenia Dolja-GoreResearch Centre for Generational Health and Ageing (RCGHA), Faculty of Health and Medicine, University of Newcastle Newcastle, NSW, Australia.

Tahne WatsonDepartment of Nuclear Medicine & PET, John Hunter and Calvary Mater Hospitals, Hunter Medical Research Institute (HMRI), University of Newcastle Newcastle, NSW, Australia.

Balakrishnan R NairSchool of Medicine and Public Health, University of Newcastle Newcastle, NSW, Australia.

John Hunter Hospital · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While reduced global brain metabolism is known in aging, Alzheimer's disease (AD), small vessel disease (SVD) and delirium, explanation of regional brain metabolic (rBM) changes is a challenge. We hypothesized that this may be explained by "triage phenomenon", to preserve metabolic supply to vital brain areas. We studied changes in rBM in 69 patients with at least 5% decline in global brain metabolism during active lymphoma. There was significant decline in the rBM of the inferior parietal, precuneus, superior parietal, lateral occipital, primary visual cortices (P<0.001) and in the right lateral prefrontal cortex (P=0.01). Some areas showed no change; multiple areas had significantly increased rBM (e.g. medial prefrontal, anterior cingulate, pons, cerebellum and mesial temporal cortices; P<0.001). We conclude the existence of a physiological triage phenomenon and argue a new hypothetical model to explain the shared events in the pathophysiology of aging, AD, SVD and delirium.

Indexed as

agingAlzheimer’s diseasecerebral metabolismcerebral perfusiondeliriumdementiasmall vessel disease

Identifiers

PMID35003887

PMCPMC8727878

OpenAlexW4206856060

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Textmetadata

Read underepoch 390

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None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.