ArticleBiomedical optics express2021
Deep imaging with 1.3 µm dual-axis optical coherence tomography and an enhanced depth of focus.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging forOptics letters · 2025Article
- Enhanced penetration depth in optical coherence tomography and photoacoustic microscopyOptica · 2025Article
- Next-generation endoscopic probe for detection of esophageal dysplasia using combined OCT and angle-resolved low-coherence interferometry.Biomedical optics express · 2024Article
- Spatially offset optical coherence tomography: Leveraging multiple scattering for high-contrast imaging at depth in turbid media.Science advances · 2023Article
- Speckle-resolved optical coherence tomography for mesoscopic imaging within scattering media.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis optical coherence tomography (DA-OCT) that offers improved depth penetration in skin imaging at 1.3 µm compared to conventional OCT. Several unique aspects of DA-OCT are examined here, including the requirements for scattering properties to realize the improvement and the limited depth of focus (DOF) inherent to the technique. To overcome this limitation, our approach uses a tunable lens to coordinate focal plane selection with image acquisition to create an enhanced DOF for DA-OCT. This improvement in penetration depth is quantified experimentally against conventional on-axis OCT using tissue phantoms and mouse skin. The results presented here suggest the potential use of DA-OCT in situations where a high degree of scattering limits depth penetration in OCT imaging.
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Registered trials
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