Evidence map›Paper›PMID 35003859›Full record

ArticleBiomedical optics express2021

Detection of carbamazepine in saliva based on surface-enhanced Raman spectroscopy.

Ning Chen, Yanbing Yuan, Ping Lu, Luyao Wang, Xuedian Zhang, Hui Chen, Pei Ma

Abstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ning ChenKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yanbing YuanKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Ping LuKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Luyao WangKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xuedian ZhangKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Hui ChenKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID https://orcid.org/0000-0002-4391-9717
Pei MaKey Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID https://orcid.org/0000-0001-8485-6065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbamazepine (CBZ) is a commonly used drug for the treatment of epilepsy. Due to the narrow effective range, CBZ concentration was usually monitored with blood draw from patients. Frequent blood draw is inconvenient and causes physical and psychological pain. Therefore, highly-sensitive, rapid, label-free, and non-invasive drug detection methods can be alternatives to bring a relief. In this work, we have proposed a method for the non-invasive detection of CBZ using surface-enhanced Raman spectroscopy (SERS). Gold-silver core-shell nanomaterial substrates were prepared and optimized. Salivary CBZ concentration was measured with SERS as a non-invasive alternative to blood draw. The results showed that there was a linear relationship between SERS response and CBZ concentration in the entire measured range of 10

Identifiers

PMID35003859
PMCPMC8713680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.