Evidence map›Paper›PMID 35003850›Full record

ArticleBiomedical optics express2021

Deep learning 2D and 3D optical sectioning microscopy using cross-modality Pix2Pix cGAN image translation.

Huimin Zhuge, Brian Summa, Jihun Hamm, J Quincy Brown

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Huimin ZhugeDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA 70118, USA.
Brian SummaDepartment of Computer Science, Tulane University, New Orleans, LA 70118, USA.
Jihun HammDepartment of Computer Science, Tulane University, New Orleans, LA 70118, USA.
J Quincy BrownDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA 70118, USA.
Tulane University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
High speed automated intraoperative microscopy of the prostate circumference to ensure tumor-free margins in radical prostatectomyR01CA222831 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI BROWN, JONATHAN QUINCY · 2018 to 2021
$1.6M
NCI NIH HHS R01 CA222831NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Structured illumination microscopy (SIM) reconstructs optically-sectioned images of a sample from multiple spatially-patterned wide-field images, but the traditional single non-patterned wide-field images are more inexpensively obtained since they do not require generation of specialized illumination patterns. In this work, we translated wide-field fluorescence microscopy images to optically-sectioned SIM images by a Pix2Pix conditional generative adversarial network (cGAN). Our model shows the capability of both 2D cross-modality image translation from wide-field images to optical sections, and further demonstrates potential to recover 3D optically-sectioned volumes from wide-field image stacks. The utility of the model was tested on a variety of samples including fluorescent beads and fresh human tissue samples.

Identifiers

PMID35003850
PMCPMC8713683
OpenAlexW3214382080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.