ArticleBiomedical optics express2021
Wavelength and pulse energy optimization for detecting hypoxia in photoacoustic imaging of the neonatal brain: a simulation study.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Efficient algorithm for optimal wavelength selection in photoacoustic spectral unmixing.Biomedical optics express · 2026Article
- Quantitative assessment of thrombosis-induced blood oxygenation change in deep tissues based on photoacoustic tomography: anBiomedical optics express · 2025Article
- Spiral laser scanning photoacoustic microscopy for functional brain imaging in rats.Neurophotonics · 2024Article
- Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation:Photoacoustics · 2023Article
- Exploring the Association between Oxygen Concentration and Life Expectancy in China: A Quantitative Analysis.International journal of environmental research and public health · 2023Article
- Review
- Couplants in Acoustic Biosensing Systems.Chemosensors (Basel, Switzerland) · 2022Review
- Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics.Frontiers in medicine · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Cerebral hypoxia is a severe injury caused by oxygen deprivation to the brain. Hypoxia in the neonatal period increases the risk for the development of neurological disorders, including hypoxic-ischemic encephalopathy, cerebral palsy, periventricular leukomalacia, and hydrocephalus. It is crucial to recognize hypoxia as soon as possible because early intervention improves outcomes. Photoacoustic imaging, using at least two wavelengths, through a spectroscopic analysis, can measure brain oxygen saturation. Due to the spectral coloring effect arising from the dependency of optical properties of biological tissues to the wavelength of light, choosing the right wavelength-pair for efficient and most accurate oxygen saturation measurement and consequently quantifying hypoxia at a specific depth is critical. Using a realistic neonate head model and Monte Carlo simulations, we found practical wavelength-pairs that quantified regions with hypoxia most accurately at different depths down to 22 mm into the cortex neighboring the lateral ventricle. We also demonstrated, for the first time, that the accuracy of the sO
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Registered trials
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