Evidence map›Paper›PMID 35003805›Full record

ArticleDepression research and treatment2021

Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study.

Velda J Gonzalez-Mercado, Jean Lim, Leorey N Saligan, Nicole Perez, Carmen Rodriguez, Raul Bernabe, Samia Ozorio, Elsa Pedro, Farrah Sepehri, Brad Aouizerat

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Velda J Gonzalez-MercadoRory Meyers College of Nursing, New York University, New York, NY, USA.ORCID https://orcid.org/0000-0002-7236-0182
Jean LimUniversity of Miami, Miami, FL, USA.
Leorey N SaliganIntramural Program, National Institute of Nursing Research/National Institute of Health, Bethesda, MD, USA.
Nicole PerezRory Meyers College of Nursing, New York University, New York, NY, USA.
Carmen RodriguezCollege of Nursing, University of South Florida, Tampa, FL, USA.
Raul BernabeDepartment of General Studies, University of Puerto Rico, San Juan, Puerto Rico.
Samia OzorioCollege of Nursing, University of South Florida, Tampa, FL, USA.
Elsa PedroSchool of Pharmacy, Medical Science Campus, University of Puerto Rico, San Juan, Puerto Rico.
Farrah SepehriCollege of Nursing, University of South Florida, Tampa, FL, USA.
Brad AouizeratBluestone Center for Clinical Research, Department of Oral and Maxillofacial Surgery College of Dentistry, New York University, New York, NY, USA.
University of South Florida · USNew York University · USCenter for Clinical Research (United States) · USNational Institute of Nursing Research · USUniversity of Miami · USUniversity of Puerto Rico, Medical Sciences Campus · PRUniversity of Puerto Rico System · PR

Funding

Multi-omic Evaluation of the mTOR pathway in Radiotherapy-Related FatigueK23NR020039 · NINR · NEW YORK UNIVERSITY · PI GONZALEZ-MERCADO, VELDA JANET · 2021 to 2023
$501k
NINR NIH HHS K23 NR020039
6 · The paper itself

Abstract

backgroundThe role of alterations in gut microbiota composition (termed dysbiosis) has been implicated in the pathobiology of depressive symptoms; however, evidence remains limited. This cross-sectional pilot study is aimed at exploring whether depressive symptom scores changed during neoadjuvant chemotherapy and radiation therapy to treat rectal cancer, and if gut microbial taxa abundances and predicted functional pathways correlate with depressive symptoms at the end of chemotherapy and radiation therapy.

methods40 newly diagnosed rectal cancer patients (ages 28-81; 23 males) were assessed for depressive symptoms using the Hamilton Rating Scale for Depression (HAM-D) and provided stool samples for 16S rRNA sequencing. Gut microbiome data were analyzed using QIIME2, and correlations and regression analyses were performed in R.

resultsParticipants had significantly higher depressive symptoms at the end as compared to before CRT. The relative abundances of

conclusionsSignificant bacterial taxa and predicted functional pathways correlated with depressive symptoms at the end of chemotherapy and radiation therapy for rectal cancer which warrants further examination and replication of our findings.

Identifiers

PMID35003805
PMCPMC8731300
OpenAlexW4200400671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.