ArticleChemical science2021
Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 63 citations in OpenAlex.
- Intracellular activated logic nanomachines based on framework nucleic acids for low background detection of microRNAs in living cells.Chemical science · 2023Article
- Programmable DNA biocomputing circuits for rapid and intelligent screening of SARS-CoV-2 variants.Biosensors & bioelectronics · 2023Article
- Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly.Chemical science · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catalytic DNA circuits represent a versatile toolbox for tracking intracellular biomarkers yet are constrained with low anti-interference capacity originating from their severe off-site activation. Herein, by introducing an unprecedented endogenous DNA repairing enzyme-powered pre-selection strategy, we develop a sequential and specific on-site activated catalytic DNA circuit for achieving the cancer cell-selective imaging of microRNA with high anti-interference capacity. Initially, the circuitry reactant is firmly caged by an elongated stabilizing duplex segment with a recognition/cleavage site of a cell-specific DNA repairing enzyme, which can prevent undesired signal leakage prior to its exposure to target cells. Then, the intrinsic DNA repairing enzyme of target cells can liberate the DNA probe for efficient intracellular microRNA imaging
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Registered trials
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