Evidence map›Paper›PMID 35003589›Full record

ArticleChemical science2021

Protamine/heparin optical nanosensors based on solvatochromism.

Yoshiki Soda, Kye J Robinson, Robin Nussbaum, Eric Bakker

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yoshiki SodaDepartment of Inorganic, Analytical Chemistry, University of Geneva Quai Ernest-Ansermet 30 1211 Geneva Switzerland Eric.Bakker@unige.ch.
Kye J RobinsonDepartment of Inorganic, Analytical Chemistry, University of Geneva Quai Ernest-Ansermet 30 1211 Geneva Switzerland Eric.Bakker@unige.ch.ORCID https://orcid.org/0000-0003-2710-4718
Robin NussbaumDepartment of Inorganic, Analytical Chemistry, University of Geneva Quai Ernest-Ansermet 30 1211 Geneva Switzerland Eric.Bakker@unige.ch.
Eric BakkerDepartment of Inorganic, Analytical Chemistry, University of Geneva Quai Ernest-Ansermet 30 1211 Geneva Switzerland Eric.Bakker@unige.ch.ORCID https://orcid.org/0000-0001-8970-4343
University of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical nanosensors for the detection of polyions, including protamine and heparin, have to date relied upon ion-exchange reactions involving an analyte and an optical transducer. Unfortunately, due to the limited selectivity of the available ionophores for polyions, this mechanism has suffered from severe interference in complex sample matrices. To date no optical polyion nanosensors have demonstrated acceptable performance in serum, plasma or blood. Herein we describe a new type of nanosensor based on our discovery of a "hyper-polarizing lipophilic phase" in which dinonylnaphthalenesulfonate (DNNS

Identifiers

PMID35003589
PMCPMC8653997
OpenAlexW3212586371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.