ReviewChemical science2021
The 100 facets of the Passerini reaction.
Review in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview.ChemMedChem · 2026Review
- Planar Chirality Directs Enantiospecific Diastereoselectivity in Isocyanide-Based Multicomponent Reactions.ACS organic & inorganic Au · 2026Article
- Multicomponent Reactions for the Synthesis of Oxazepines.Topics in current chemistry (Cham) · 2026Review
- Kinetics and Mechanism of the Enantioselective Passerini Multicomponent Reaction Catalyzed by Chiral Ionic Liquids.ACS omega · 2026Article
- Non-innocent behaviour of aromatic isocyanides under visible light: a pathway to thioformimidates and dehydroalanine.Chemical science · 2026Article
- Harnessing PNature communications · 2026Article
- Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins.Communications chemistry · 2026Article
- An Accurate and Efficient Reaction Path Search with Iteratively Trained Neural Network Potential: Answering the Passerini Mechanism Controversy.Journal of chemical theory and computation · 2026Article
- An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation.The FEBS journal · 2025Article
- Photoexcited Palladium Complex-Catalyzed Isocyanide Insertion into Inactivated Alkyl Iodides.Molecules (Basel, Switzerland) · 2025Article
- Multicomponent Hosomi-Sakurai reaction on chiral, bio-based, alcohols.RSC advances · 2025Article
- Strong Hydrogen Bond Donating Solvents Accelerate the Passerini Three-Component Reaction.The Journal of organic chemistry · 2025Article
- Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomimetics.Organic letters · 2025Article
- Accessing Promising Passerini Adducts in Anticancer Drug Design.Molecules (Basel, Switzerland) · 2024Article
- Total Synthesis of 4-Molecules (Basel, Switzerland) · 2024Article
- 100 years of isocyanide-based multicomponent reactions.Molecular diversity · 2024Article
- New oxacycles on the block: benzodioxepinones via a Passerini reaction.Molecular diversity · 2024Article
- Cyrene: a very reactive bio-based chiral ketone in diastereoselective Passerini reactions.Molecular diversity · 2024Article
- The Groebke-Blackburn-Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019-2023).Beilstein journal of organic chemistry · 2024Review
- Deuterated reagents in multicomponent reactions to afford deuterium-labeled products.Beilstein journal of organic chemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction. After being nearly neglected for many years, now this reaction has become quite popular, thanks to the achievements of the last 30 years, which have revealed several chances of exploitation in organic synthesis. Though not being comprehensive, this review means to show the various ways that have been used in order to expand the utility of the Passerini reaction. Post-MCR transformations to give heterocycles or peptidomimetics, variants through single component replacement, stereochemical issues, and applications in total syntheses will be especially covered.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.