Evidence map›Paper›PMID 35003513›Full record

ArticleOxidative medicine and cellular longevity2021

TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.

Yuxin Luo, Jinbo Guo, Wenxiu Jia, Mengyao Wu, Fengrong Yin, Guochao Niu, David Q Shih, Stephan R Targan, Xiaolan Zhang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yuxin LuoDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-3686-1377
Jinbo GuoDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0001-9418-600X
Wenxiu JiaDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-1105-0746
Mengyao WuDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0003-0510-8654
Fengrong YinDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-3794-9522
Guochao NiuDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.
David Q ShihF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, USA.ORCID https://orcid.org/0000-0003-1335-7044
Stephan R TarganF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, USA.ORCID https://orcid.org/0000-0003-0265-5193
Xiaolan ZhangDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-7047-3634
Hebei Medical University · CNCedars-Sinai Medical Center · US

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
NIDDK NIH HHS P01 DK046763
6 · The paper itself

Abstract

Nonalcoholic steatohepatitis (NASH) is a progressive, chronic liver disease worldwide which imposes a large economic burden on society. M1/M2 macrophage balance destruction and recruitment of mononuclear immune cells to the liver play critical roles in NASH. Several studies have shown that the expression of TNF-like ligand 1 aberrance (TL1A) increased in macrophages associated with many inflammatory diseases, for example, inflammatory bowel disease, primary biliary cholangitis, and liver fibrosis. One recent research showed that weight, abdominal adipose, and liver leptin, one of the critical fat cytokines, were reduced in

Indexed as

AnimalsDisease Models, AnimalHumansLigandsMacrophage ActivationMacrophagesMiceMice, TransgenicNon-alcoholic Fatty Liver DiseaseTumor Necrosis Factor-alphaLigandsTumor Necrosis Factor-alpha

Identifiers

PMID35003513
PMCPMC8741351
OpenAlexW4205893352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.