Evidence map›Paper›PMID 35003209›Full record

ArticleFrontiers in genetics2021

A Haptoglobin Exon Copy Number Variant Associates With HIV-Associated Neurocognitive Impairment in European and African-Descent Populations.

Haimeng Bai, Harpreet Kaur, Asha R Kallianpur, Todd Hulgan, Donald R Franklin, Scott L Letendre, Ronald J Ellis, William S Bush

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Haimeng BaiDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, United States.
Harpreet KaurDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Asha R KallianpurDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Todd HulganDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
Donald R FranklinDepartment of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, CA, United States.
Scott L LetendreDepartments of Medicine and Psychiatry, University of California, San Diego, San Diego, CA, United States.
Ronald J EllisDepartments of Neurosciences and Psychiatry, University of California, San Diego, San Diego, CA, United States.
William S BushDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, United States.
University of California, San Diego · USUniversity School · USCase Western Reserve University · USCleveland Clinic · USVanderbilt University · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Iron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER StudyR01MH095621 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HULGAN, TODD M, KALLIANPUR, ASHA R · 2011 to 2015
$3.1M
Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and GeneticsR01MH124530 · NIMH · CLEVELAND CLINIC LERNER COM-CWRU · PI KALLIANPUR, ASHA R · 2021 to 2025
$2.4M
NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH095621NIMH NIH HHS R01 MH107345NIMH NIH HHS R01 MH124530
6 · The paper itself

Abstract

A common two-exon deletion distinguishes the gene encoding the free hemoglobin capturing protein-haptoglobin (HP)-into two alleles:

Indexed as

ageCHARTERgenetic imputationhaptoglobinHIVHIV-associated neurocognitive disorderlongitudinalneurocognitive impairment

Identifiers

PMID35003209
PMCPMC8727522
OpenAlexW4200113829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.