Evidence map›Paper›PMID 35003035›Full record

ArticleFrontiers in microbiology2021

Dioctanoyl Ultrashort Tetrabasic β-Peptides Sensitize Multidrug-Resistant Gram-Negative Bacteria to Novobiocin and Rifampicin.

Danyel Ramirez, Liam Berry, Ronald Domalaon, Yanqi Li, Gilbert Arthur, Ayush Kumar, Frank Schweizer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Effects of LysineAntibiotics (Basel, Switzerland) · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danyel RamirezDepartment of Chemistry, University of Manitoba, Winnipeg, MB, Canada.
Liam BerryDepartment of Chemistry, University of Manitoba, Winnipeg, MB, Canada.
Ronald DomalaonDepartment of Chemistry, University of Manitoba, Winnipeg, MB, Canada.
Yanqi LiDepartment of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Gilbert ArthurDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Ayush KumarDepartment of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Frank SchweizerDepartment of Chemistry, University of Manitoba, Winnipeg, MB, Canada.
University of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently reported peptidomimetics with increased resistance to trypsin were shown to sensitize priority multidrug-resistant (MDR) Gram-negative bacteria to novobiocin and rifampicin. To further optimize proteolytic stability, β-amino acid-containing derivatives of these compounds were prepared, resulting in three dioctanoyl ultrashort tetrabasic β-peptides (dUSTBβPs). The nonhemolytic dUSTBβP 3, comprised of three β

Indexed as

Acinetobacter baumanniiantibiotic adjuvantEscherichia colinovobiocinpeptidomimeticPseudomonas aeruginosarifampicinβ-amino acid

Identifiers

PMID35003035
PMCPMC8733726
OpenAlexW4200086372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.