Evidence map›Paper›PMID 35002976›Full record

ReviewFrontiers in endocrinology2021

Signaling Proteins That Regulate Spermatogenesis Are the Emerging Target of Toxicant-Induced Male Reproductive Dysfunction.

Sheng Gao, Xiaolong Wu, Lingling Wang, Tiao Bu, Adolfo Perrotta, Giuseppe Guaglianone, Bruno Silvestrini, Fei Sun, C Yan Cheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sheng GaoDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaolong WuDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lingling WangDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Tiao BuDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Adolfo PerrottaDepartment of Translational & Precision Medicine, Sapienza University of Rome, Rome, Italy.
Giuseppe GuaglianoneDepartment of Hospital Pharmacy, "Azienda Sanitaria Locale (ASL) Roma 4", Civitavecchia, Italy.
Bruno SilvestriniInstitute of Pharmacology and Pharmacognosy, Sapienza University of Rome, Rome, Italy.
Fei SunDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
C Yan ChengDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University · CNSapienza University of Rome · ITSir Run Run Shaw Hospital · CNASL Roma · ITNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is emerging evidence that environmental toxicants, in particular endocrine disrupting chemicals (EDCs) such as cadmium and perfluorooctanesulfonate (PFOS), induce Sertoli cell and testis injury, thereby perturbing spermatogenesis in humans, rodents and also widelife. Recent studies have shown that cadmium (e.g., cadmium chloride, CdCl

Indexed as

Alkanesulfonic AcidsAnimalsEndocrine DisruptorsEnvironmental PollutantsFluorocarbonsHumansIntracellular Signaling Peptides and ProteinsMaleReproductionSertoli CellsSignal TransductionSpermatogenesisTestisAlkanesulfonic AcidsEndocrine DisruptorsEnvironmental PollutantsFluorocarbonsIntracellular Signaling Peptides and Proteinsperfluorooctane sulfonic acidcytoskeletonsendocrine disrupting chemicalsmale reproductionSertoli cellsspermatogenesistestis

Identifiers

PMID35002976
PMCPMC8739942
OpenAlexW4200415613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.