SynthesisFrontiers in endocrinology2021
The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies.
Synthesis in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 7 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Habitual physical activity and sarcopenia: a systematic review and meta-analysis of prospective cohort studies.Journal of global health · 2026Pooled it
- Pooled it
- Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis.Journal of diabetes investigation · 2026Pooled it
- The association of sarcopenia, possible sarcopenia and cognitive impairment: A systematic review and meta-analysis.PloS one · 2025Pooled it
- The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.GeroScience · 2024Pooled it
- Prevalence of sarcopenia and its association with clinical outcomes in heart failure: An updated meta-analysis and systematic review.Clinical cardiology · 2023Pooled it
- Pulse Wave Velocity and Sarcopenia in Older Persons-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Low-calorie, high-protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity.Diabetes, obesity & metabolism · 2025Trial
- Prevalence, risk factors and adverse health outcomes of osteosarcopenia in middle-aged and older adults with type 2 diabetes mellitus-a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Heterogeneous associations between domain-specific physical activity and sarcopenia risk in diabetic adults: A causal forest analysis.The Journal of international medical research · 2026Article
- Metabolic-inflammatory axis linking diabetes and sarcopenia: cross-population evidence and explainable ai-based risk modeling.Acta diabetologica · 2026Article
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- Article
- Skeletal Muscle Loss During Neoadjuvant Chemotherapy for Breast Cancer: Diabetes as an Independent Predictor.European journal of breast health · 2026Article
- The bidirectional relationship between diabetes and poor muscle function in older adults: data from two population-based studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
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- Association between diabetes and sarcopenia in US adults and the role of adiposity: a survey-weighted analysis of NHANES 2011-2018.BMC public health · 2026Article
- Associations of Free Triiodothyronine With Sarcopenia Among Patients With Type 2 Diabetes: Cross-Sectional and Sex-Stratified Analyses.Journal of diabetes research · 2026Article
- Traditional Chinese Medicine for Diabetic Sarcopenia: A Review and Its Related Mechanisms.Journal of diabetes research · 2026Review
- Association between CVAI-defined body composition phenotypes and prediabetes outcomes in Chinese adults undergoing health check-ups: a cross-sectional study.Frontiers in nutrition · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: We performed a meta-analysis of observational studies to evaluate the association between the presence of sarcopenia and HbA1c, prediabetes, diabetes and diabetic complications. Method: The PubMed, Embase, Cochrane and Web of Science databases were searched from inception to May 2021. We included full-text English language articles that reported the prevalence of sarcopenia in patients with and without diabetes. Quality assessment was performed according to the Newcastle- Ottawa scale for observational studies. Results: Sixteen studies were included in the meta-analysis. Three studies showed that high HbA1c levels lead to loss of muscle mass, and one study involving prediabetes showed that people with prediabetes had lower muscle mass, strength, and performance than non-diabetic population. Seven studies showed that people with diabetes had a higher risk of sarcopenia than those without diabetes (combined OR: 2.09, 95% CI:1.62-2.70). The remaining five studies suggested that diabetic complications increased the risk of sarcopenia (combined OR: 2.09,95% CI:1.62-2.70). Conclusion: High HbA1c levels, prediabetes, diabetes and diabetes complications were associated with an increased risk of sarcopenia. Therapeutic strategies addressed to avoid the conversion of IGT to diabetes and to optimize glycemic control are warranted to prevent or arrest sarcopenia in the diabetic population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.