Evidence map›Paper›PMID 35002964›Full record

ArticleFrontiers in endocrinology2021

Feasibility of an Inversion Recovery-Prepared Fat-Saturated Zero Echo Time Sequence for High Contrast Imaging of the Osteochondral Junction.

Hyungseok Jang, Yajun Ma, Michael Carl, Alecio F Lombardi, Eric Y Chang, Jiang Du

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hyungseok JangDepartment of Radiology, University of California, San Diego, CA, United States.
Yajun MaDepartment of Radiology, University of California, San Diego, CA, United States.
Michael CarlGE Healthcare, San Diego, CA, United States.
Alecio F LombardiDepartment of Radiology, University of California, San Diego, CA, United States.
Eric Y ChangDepartment of Radiology, University of California, San Diego, CA, United States.
Jiang DuDepartment of Radiology, University of California, San Diego, CA, United States.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of BoneR01AR068987 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2024
$4.9M
Quantitative UTE MR Imaging: Sensitive Biomarkers for OsteoarthritisR01AR062581 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2013 to 2022
$4.1M
Resource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)P30AR073761 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CORR, MARY P · 2018 to 2022
$3.9M
Ultrashort Echo Time Magnetic Resonance Imaging of Hemophilic ArthropathyR01AR078877 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JANG, HYUNGSEOK · 2021 to 2025
$2.4M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
Three-Dimensional UTE Magnetic Resonance Imaging of the Osteochondral JunctionR21AR075851 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MA, YAJUN · 2020 to 2021
$376k
CSRD VA I01 CX001388NIAMS NIH HHS P30 AR073761NIAMS NIH HHS R01 AR062581NIAMS NIH HHS R01 AR068987NIAMS NIH HHS R01 AR075825NIAMS NIH HHS R01 AR078877NIAMS NIH HHS R21 AR075851RRD VA I01 RX002604
6 · The paper itself

Abstract

Purpose: The osteochondral junction (OCJ) region-commonly defined to include the deep radial uncalcified cartilage, tidemark, calcified cartilage, and subchondral bone plate-functions to absorb mechanical stress and is commonly associated with the pathogenesis of osteoarthritis. However, magnetic resonance imaging of the OCJ region is difficult due to the tissues' short transverse relaxation times (i.e., short T Method: An IR-FS-ZTE MR sequence was developed to image the OCJ on a clinical 3T MRI scanner. The IR-FS-ZTE sequence employed an adiabatic inversion pulse followed by a fat saturation pulse that suppressed signals from the articular cartilage and fat. At an inversion time (TI) that was matched to the nulling point of the articular cartilage, continuous ZTE imaging was performed with a smoothly rotating readout gradient, which enabled time-efficient encoding of the OCJ region's short T Results: In the Conclusion: IR-FS-ZTE allows direct imaging of the OCJ region of the human knee and may help in elucidating the role of the OCJ in cartilage degeneration.

Indexed as

AdultAgedAutopsyCartilage, ArticularContrast MediaFeasibility StudiesHealthy VolunteersHumansImaging, Three-DimensionalKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritisContrast Mediacartilageinversion recoveryosteoarthritisosteochondral junctionUTEZTE

Identifiers

PMID35002964
PMCPMC8739813
OpenAlexW4200597843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.