Evidence map›Paper›PMID 35002918›Full record

ArticleFrontiers in neurology2021

Sedation-Induced Burst Suppression Predicts Positive Outcome Following Traumatic Brain Injury.

Joel Frohlich, Micah A Johnson, David L McArthur, Evan S Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M Spivak, Jesús E Ruiz Tejeda, Paul M Vespa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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  9. Protective down-regulated states in the human brain: A possible lesson from COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joel FrohlichDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Micah A JohnsonDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
David L McArthurDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Evan S LutkenhoffDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
John Dell'ItaliaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Courtney RealDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Vikesh ShresthaDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Norman M SpivakDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Jesús E Ruiz TejedaDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Paul M VespaDepartment of Neurosurgery, Brain Injury Research Center (BIRC), UCLA Brain Injury Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Martin M MontiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
The effects of glycemic control on post-traumatic brain metabolismP01NS058489 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTTON, RICHARD L. · 2009 to 2013
$6.2M
MRS Detects Metabolic Dysfunction after Brain InjuryR01NS049471 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VESPA, PAUL M · 2006 to 2009
$1.3M
NINDS NIH HHS P01 NS058489NINDS NIH HHS R01 NS049471NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

While electroencephalogram (EEG) burst-suppression is often induced therapeutically using sedatives in the intensive care unit (ICU), there is hitherto no evidence with respect to its association to outcome in moderate-to-severe neurological patients. We examined the relationship between sedation-induced burst-suppression (SIBS) and outcome at hospital discharge and at 6-month follow up in patients surviving moderate-to-severe traumatic brain injury (TBI). For each of 32 patients recovering from coma after moderate-to-severe TBI, we measured the EEG burst suppression ratio (BSR) during periods of low responsiveness as assessed with the Glasgow Coma Scale (GCS). The maximum BSR was then used to predict the Glasgow Outcome Scale extended (GOSe) at discharge and at 6 months post-injury. A multi-model inference approach was used to assess the combination of predictors that best fit the outcome data. We found that BSR was positively associated with outcomes at 6 months (

Indexed as

barbituratesburst suppressioncomadisorders of consciousnessEEG biomarkerGlasgow Coma Scale (GCS)Glasgow Outcome Scale extended (GOSe)traumatic brain injury (TBI)

Identifiers

PMID35002918
PMCPMC8727767
OpenAlexW4200371151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.