Evidence map›Paper›PMID 35002645›Full record

ArticleFrontiers in behavioral neuroscience2021

Anatomical and Functional Characterization of Central Amygdala Glucagon-Like Peptide 1 Receptor Expressing Neurons.

Ningxiang Zeng, Elam J Cutts, Christian B Lopez, Simran Kaur, Miguel Duran, Sonja A Virkus, J Andrew Hardaway

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  10. Mechanisms of glucagon-like-peptide 1 in the brain beyond metabolic effects.Annals of pediatric endocrinology & metabolism · 2025
    Article
  11. Review
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  14. Spotlight on the Mechanism of Action of Semaglutide.Current issues in molecular biology · 2024
    Review
  15. Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ningxiang ZengDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Elam J CuttsDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Christian B LopezDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Simran KaurDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Miguel DuranDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Sonja A VirkusDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
J Andrew HardawayDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
A Nociceptin Central Amygdala to Hindbrain Circuit for the Control of Palatable Food ConsumptionK01DK115902 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARDAWAY, JAMES ANDREW · 2018 to 2022
$697k
Functional and Behavioral Characterization of Central Amygdala Glucagon Like Peptode-1 ReceptorsR03DK129561 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARDAWAY, JAMES ANDREW · 2021 to 2022
$333k
NIDDK NIH HHS K01 DK115902NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R03 DK129561
6 · The paper itself

Abstract

Glucagon-like peptide 1 receptors (GLP-1Rs) are highly expressed in the brain and are responsible for mediating the acute anorexigenic actions of widely prescribed GLP-1R agonists. Neurobiological efforts to localize the hypophagic effects of GLP-1R agonists in the brain have mainly focused on the hypothalamus and hindbrain. In this study, we performed a deep anatomical and neurophysiological characterization of GLP-1Rs in the central nucleus of the amygdala (CeA). At an mRNA level, we found that

Indexed as

anatomycentral amygdala (CeA)electrophysiologyglucagon-like peptide 1 (GLP-1)glucagon-like peptide 1 receptor (GLP-1R)neural circuit

Identifiers

PMID35002645
PMCPMC8739476
OpenAlexW4200312699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.