ArticleFrontiers in neuroanatomy2021
A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice.
Article in Frontiers in neuroanatomy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Glycosaminoglycan sugar side chains on perineuronal nets in the fastigial nucleus regulate motor skills.iScience · 2025Article
- GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.Nature communications · 2024Article
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- G protein-coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects.British journal of pharmacology · 2024Review
- Where Top-Down Meets Bottom-Up: Cell-Type Specific Connectivity Map of the Whisker System.Neuroinformatics · 2024Article
- Article
- State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice.Frontiers in neural circuits · 2023Article
- Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms?Frontiers in systems neuroscience · 2023Review
- Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Article
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12 authors.
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Abstract
The glutamatergic and GABAergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) mediated diverse brain functions. However, their whole-brain neural connectivity has not been comprehensively mapped. Here we used the virus tracers to characterize the whole-brain inputs and outputs of glutamatergic and GABAergic neurons in VTA and SNc. We found that these neurons received similar inputs from upstream brain regions, but some quantitative differences were also observed. Neocortex and dorsal striatum provided a greater share of input to VTA glutamatergic neurons. Periaqueductal gray and lateral hypothalamic area preferentially innervated VTA GABAergic neurons. Specifically, superior colliculus provided the largest input to SNc glutamatergic neurons. Compared to input patterns, the output patterns of glutamatergic and GABAergic neurons in the VTA and SNc showed significant preference to different brain regions. Our results laid the anatomical foundation for understanding the functions of cell-type-specific neurons in VTA and SNc.
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