Evidence map›Paper›PMID 35002618›Full record

ArticleFrontiers in molecular neuroscience2021

TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human.

Jean Marie Delalande, Nandor Nagy, Conor J McCann, Dipa Natarajan, Julie E Cooper, Gabriela Carreno, David Dora, Alison Campbell, Nicole Laurent, Polychronis Kemos and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 6 countries.

Jean Marie DelalandeCentre for Immunobiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Nandor NagyDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Conor J McCannStem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Dipa NatarajanStem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Julie E CooperDevelopmental Biology and Cancer Program, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Gabriela CarrenoDevelopmental Biology and Cancer Program, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
David DoraDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.
Alison CampbellDepartment of Paediatric Surgery, Christchurch Hospital, Christchurch, New Zealand.
Nicole LaurentGénétique et Anomalies du Développement, Université de Bourgogne, Service d'Anatomie Pathologique, Dijon, France.
Polychronis KemosCentre for Immunobiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Sophie ThomasLaboratory of Embryology and Genetics of Congenital Malformations, INSERM UMR 1163 Institut Imagine, Paris, France.
Caroline AlbyDepartment of Genetics, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France.
Tania Attié-BitachLaboratory of Embryology and Genetics of Congenital Malformations, INSERM UMR 1163 Institut Imagine, Paris, France.
Stanislas LyonnetLaboratory of Embryology and Genetics of Congenital Malformations, INSERM UMR 1163 Institut Imagine, Paris, France.
Malcolm P LoganRandall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.
Allan M GoldsteinDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Megan G DaveyDivision of Developmental Biology, The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Robert M W HofstraDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands.
Nikhil ThaparStem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Alan J BurnsStem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Great Ormond Street Hospital · GBUniversity College London · GBInserm · FRSemmelweis University · HUChristchurch Hospital · NZErasmus MC · NLHarvard University · USHôpital Necker-Enfants Malades · FRKing's College London · GBQueen Mary University of London · GBRoslin Institute · GBSorbonne Paris Cité · FRUniversité de Bourgogne · FR

Funding

Biotechnology and Biological Sciences Research Council BB/F024347/1Biotechnology and Biological Sciences Research Council BBS/E/D/20320000
6 · The paper itself

Abstract

TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analyzed chicken, mouse and human embryonic GI tissues with TALPID3 mutations. The GI tract of TALPID3 chicken embryos was shortened and malformed. Histologically, the gut smooth muscle was mispatterned and enteric neural crest cells were scattered throughout the gut wall. Analysis of the Hedgehog pathway and gut extracellular matrix provided causative reasons for these defects. Interestingly, chicken intra-species grafting experiments and a conditional knockout mouse model showed that ENS formation did not require TALPID3, but was dependent on correct environmental cues. Surprisingly, the lack of TALPID3 in enteric neural crest cells (ENCC) affected smooth muscle and epithelial development in a non-cell-autonomous manner. Analysis of human gut fetal tissues with a

Indexed as

enteric nervous systemgastrointestinal tractJoubert syndromeKIAA0586neural crest cellshort-rib polydactyly syndromeSonic HedgehogTALPID3

Identifiers

PMID35002618
PMCPMC8733242
OpenAlexW4225984597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.