Evidence map›Paper›PMID 35002520›Full record

ArticleInternational journal of biological sciences2022

Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway.

Zirui Liu, Yiquan Li, Yilong Zhu, Nan Li, Wenjie Li, Chao Shang, Gaojie Song, Shanzhi Li, Jianan Cong, Tingyu Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
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  5. How to recognize if a cell dies from pyroptosis?Molecular biology reports · 2026
    Review
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  8. Review
  9. Review
  10. Article
  11. Article
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  16. Article
  17. Prognostic Significance and Immune Environment Analysis Using PANoptosis Molecular Clustering in Gastric Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Zirui LiuCollege of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Yiquan LiAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, 130021, China.
Yilong ZhuAcademician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, 130021, China.
Nan LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Wenjie LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Chao ShangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Gaojie SongChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Shanzhi LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Jianan CongChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Tingyu LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Zhiru XiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Jing LuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Chenchen GeChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Xia YangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Yaru LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Lili SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Xiao LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 130122, China.
Ningyi JinCollege of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Jilin University · CNJilin Province Tumor Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptin is a small molecular weight protein encoded by the VP3 gene of chicken anemia virus (CAV). It can induce apoptosis of tumor cells and play anti-tumorigenic functions. In this study, we identified a time-dependent inhibitory role of apoptin on the viability of HCT116 cells. We also demonstrated that apoptin induces pyroptosis through cleaved caspase 3, and with a concomitant cleavage of gasdermin E (GSDME) rather than GSDMD. GSDME knockdown switched the apoptin-induced cell death from pyroptosis to apoptosis

Indexed as

PyroptosisAnimalsbcl-2-Associated X ProteinCaspase 3Caspase 9Colorectal NeoplasmsCytochromes cFemaleGasderminsHCT116 CellsHumansMiceMice, Inbred BALB CMice, NudeMitochondriaPore Forming Cytotoxic Proteinsbcl-2-Associated X ProteinCaspase 3Caspase 9Cytochromes cGasderminsGSDME protein, humanPore Forming Cytotoxic ProteinsReactive Oxygen Species

Identifiers

PMID35002520
PMCPMC8741846
OpenAlexW4200114539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.