Evidence map›Paper›PMID 35001898›Full record

ArticleJournal of Parkinson's disease2022

Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder.

Sheida Zolfaghari, Natalia Lewandowski, Amelie Pelletier, Seyed Ali Naeimi, Jean-François Gagnon, Marina Brillon-Corbeil, Jacques Y Montplaisir, Ronald B Postuma

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sheida ZolfaghariIntegrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Natalia LewandowskiFaculty of Science, McGill University, Montreal, Quebec, Canada.
Amelie PelletierResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Seyed Ali NaeimiResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Jean-François GagnonCentre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Marina Brillon-CorbeilCentre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Jacques Y MontplaisirCentre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
Ronald B PostumaResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
McGill University Health Centre · CAUniversité du Québec à Montréal · CAHôpital du Sacré-Cœur de Montréal · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. This prospective cohort study evaluated whether cardiovascular diseases and metabolic risk factors alter the rate or type of phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to parkinsonism or dementia. Polysomnography-confirmed iRBD patients recruited between 2004 and 2020 were followed annually. Baseline history of cardiovascular disorders, hypertension, hypercholesterolemia, and diabetes were compared among patients who developed outcomes versus those who remained outcome-free. No atherosclerotic risk factors were associated with development of α-synucleinopathies. Patients with hypercholesterolemia were somewhat more likely to develop dementia with Lewy bodies rather than Parkinson's disease.

Indexed as

Cardiovascular DiseasesHypercholesterolemiaParkinson DiseaseREM Sleep Behavior DisorderSynucleinopathiesHeart Disease Risk FactorsHumansProspective StudiesRisk Factorscardiovascular diseasecohortdementia with Lewy bodiesdiabeteshypercholesterolemiahypertensionParkinson’s diseaseREM sleep behavior disorderα-synucleinopathies

Identifiers

PMID35001898
PMCPMC9789479
OpenAlexW4205743391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.