Evidence map›Paper›PMID 35001894›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Associations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study.

Michelle C Johansen, Wendy Wang, Michael J Zhang, Alvaro Alonso, Dean F Wong, Rebecca F Gottesman, Lin Y Chen

Open access · greenAbstract readLetter
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Michelle C JohansenDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wendy WangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Michael J ZhangCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Dean F WongDepartment of Radiology, Washington University, St Louis, MO, USA.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, USA.
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota Medical Center · USEmory University · USJohns Hopkins Medicine · USNational Institute of Neurological Disorders and Stroke · USUniversity of Minnesota · USWashington University in St. Louis · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
The ARIC-PET Amyloid Imaging StudyR01AG040282 · NIA · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF, SPIRA, ADAM PETER · 2011 to 2021
$7.1M
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related DementiasR01AG075883 · NIA · JOHNS HOPKINS UNIVERSITY · PI Lin Yee Chen, Ciprian M Crainiceanu · 2022 to 2026
$3.8M
Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling ElderlyR01HL126637 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2016 to 2020
$3.7M
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive DeclineR01HL141288 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2018 to 2021
$2.1M
Defining the role of Atrial Cardiopathy and Subclinical Cardiac Disease in Acute Ischemic Stroke: Critical Life Event SupplementK23NS112459 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JOHANSEN, MICHELLE C. · 2020 to 2024
$1.0M
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's diseaseK24AG052573 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOTTESMAN, REBECCA F · 2016 to 2020
$803k
Mentoring and Research to ClassifyAtrial CardiomyopathyK24HL155813 · NHLBI · UNIVERSITY OF MINNESOTA · PI Lin Yee Chen · 2021 to 2026
$770k
Mentoring in patient-oriented atrial fibrillation and cardiovascular researchK24HL148521 · NHLBI · EMORY UNIVERSITY · PI ALONSO, ALVARO · 2019 to 2023
$593k
Determinants of Alzheimer's Disease in Atrial Fibrillation apart from Stroke: The NOMINATE StudyR21NS126967 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JOHANSEN, MICHELLE C. · 2022 to 2023
$466k
American Heart Association-American Stroke Association 16EIA26410001NHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K24 HL148521NHLBI NIH HHS K24 HL155813NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL141288NHLBI NIH HHS U01 HL096812NIA NIH HHS K24 AG052573NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG040282NIA NIH HHS R01 AG075883NINDS NIH HHS K23 NS112459NINDS NIH HHS R21 NS126967
6 · The paper itself

Abstract

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

Indexed as

Atrial FibrillationBrainAgedAmyloid beta-PeptidesAniline CompoundsCognitionHumansPositron-Emission TomographyAmyloid beta-PeptidesAniline CompoundsArrhythmiasatrial fibrillationcognitive impairmentimaging

Identifiers

PMID35001894
PMCPMC8996481
OpenAlexW4206657538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.