Evidence map›Paper›PMID 35001849›Full record

ArticleBioengineered2022

3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.

Bo Yang, Shihao Hou, Jingjing Zhao, Yepeng Li

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bo YangDepartment of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Shihao HouSchool of Clinical Medicine, Graduate School of Youjiang Medical University for Nationalities, Baise, P.R. China.
Jingjing ZhaoSchool of Clinical Medicine, Graduate School of Youjiang Medical University for Nationalities, Baise, P.R. China.
Yepeng LiDepartment of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.
Affiliated Hospital of Youjiang Medical University for Nationalities · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The implications of the CD40-CD40 ligand (CD40L) signaling pathway in systemic lupus erythematosus (SLE) were well documented, due to its important role among immune cells. Previous research found that 3-hydroxy butyrate dehydrogenase 2 (BDH2), a modulator of intracellular iron homeostasis and iron transportation promoted the pathogenic process of SLE by regulating the demethylation of

Indexed as

AnimalsCD40 LigandDisease Models, AnimalFemaleHydroxybutyrate DehydrogenaseLupus Erythematosus, SystemicMethylationMiceMice, Inbred BALB CTh1 CellsTh2 CellsCD40 LigandHydroxybutyrate Dehydrogenase3-hydroxy butyrate dehydrogenase 2CD40LCD4+ T cellsdemethylationSystemic lupus erythematosus

Identifiers

PMID35001849
PMCPMC8973909
OpenAlexW4205262355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.