Evidence map›Paper›PMID 35001672›Full record

ArticleJournal of the American Heart Association2022

Outcome of Antibody-Mediated Fetal Heart Disease With Standardized Anti-Inflammatory Transplacental Treatment.

Wadi Mawad, Lisa Hornberger, Bettina Cuneo, Marie-Josée Raboisson, Anita J Moon-Grady, Jane Lougheed, Karim Diab, Julia Parkman, Earl Silverman, Edgar Jaeggi

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Reversal of evolving third-degree atrioventricular block in utero by early detection and combination therapy.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Diagnosis and Management of Fetal Arrhythmias in the Current Era.Journal of cardiovascular development and disease · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Fetal Arrhythmia Diagnosis and Pharmacologic Management.Journal of clinical pharmacology · 2022
    Review
  17. To Be or Not to Be: Surviving Immune-Mediated Fetal Heart Disease.Journal of the American Heart Association · 2022
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Wadi MawadThe Hospital for Sick Children Toronto Ontario Canada.
Lisa HornbergerStollery Children's Hospital University of Alberta Edmonton Alberta Canada.ORCID 0000-0002-2285-3202
Bettina CuneoChildren's Hospital Colorado Denver CO.ORCID 0000-0001-9085-0882
Marie-Josée RaboissonCentre Hospitalier Universitaire Sainte Justine Montréal Quebec Canada.
Anita J Moon-GradyUCSF Benioff Children's Hospital San Francisco CA.ORCID 0000-0003-3822-693X
Jane LougheedChildren's Hospital of Eastern Ontario Ottawa Ontario Canada.
Karim DiabRush University Medical Center Chicago IL.ORCID 0000-0003-1690-7128
Julia ParkmanStollery Children's Hospital University of Alberta Edmonton Alberta Canada.
Earl SilvermanThe Hospital for Sick Children Toronto Ontario Canada.
Edgar JaeggiThe Hospital for Sick Children Toronto Ontario Canada.
Hospital for Sick Children · CAUniversity of Alberta · CACentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital Colorado · USChildren's Hospital of Eastern Ontario · CARush University Medical Center · USUCSF Benioff Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Transplacental fetal treatment of immune-mediated fetal heart disease, including third-degree atrioventricular block (AVB III) and endocardial fibroelastosis, is controversial. Methods and Results To study the impact of routine transplacental fetal treatment, we reviewed 130 consecutive cases, including 108 with AVB III and 22 with other diagnoses (first-degree/second-degree atrioventricular block [n=10]; isolated endocardial fibroelastosis [n=9]; atrial bradycardia [n=3]). Dexamethasone was started at a median of 22.4 gestational weeks. Additional treatment for AVB III included the use of a β-agonist (n=47) and intravenous immune globulin (n=34). Fetal, neonatal, and 1-year survival rates with AVB III were 95%, 93%, and 89%, respectively. Variables present at diagnosis that were associated with perinatal death included an atrial rate <90 beats per minute (odds ratio [OR], 258.4; 95% CI, 11.5-5798.9;

Indexed as

Atrioventricular BlockEndocardial FibroelastosisFetal DiseasesAntibodiesAnti-Inflammatory AgentsChildChild, PreschoolDexamethasoneFemaleHumansImmunoglobulins, IntravenousInfant, NewbornPregnancyAntibodiesAnti-Inflammatory AgentsDexamethasoneImmunoglobulins, Intravenouscardiomyopathyfetalheart blockoutcomesteroidstreatment

Identifiers

PMID35001672
PMCPMC9238501
OpenAlexW4205660241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.